IL-1 Beta—A Biomarker for Ischemic Stroke Prognosis and Atherosclerotic Lesions of the Internal Carotid Artery

Background and Objectives: Stroke is a leading cause of mortality and morbidity worldwide. Treatment of this pathology is still under development and its risk factors remain to be determined. Therefore, we aim to determine the role of interleukin-1 beta in atherosclerotic lesions of the internal car...

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Published inMedicina (Kaunas, Lithuania) Vol. 59; no. 10; p. 1790
Main Authors Catană, Maria-Gabriela, Popențiu, Ioan-Adrian, Văleanu, Mădălina, Roman-Filip, Corina, Mihăilă, Romeo-Gabriel
Format Journal Article
LanguageEnglish
Published Basel MDPI AG 01.10.2023
MDPI
Subjects
atheromatosis
Atherosclerosis
biomarker
Biomarkers
Carotid arteries
Cytokines
Ethylenediaminetetraacetic acid
Health aspects
Infections
inflammation
Injuries
interleukin-1 beta
Interleukins
Ischemia
Medical research
Medicine, Experimental
Normal distribution
Pathology
Prognosis
Statistical analysis
Stroke
Stroke (Disease)
Tumor necrosis factor-TNF
Ultrasonic imaging
Veins & arteries
Romania
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Summary:Background and Objectives: Stroke is a leading cause of mortality and morbidity worldwide. Treatment of this pathology is still under development and its risk factors remain to be determined. Therefore, we aim to determine the role of interleukin-1 beta in atherosclerotic lesions of the internal carotid artery as a risk factor for stroke and the role of this biomarker in stroke prognosis. Materials and Methods: This study enrolled 56 patients diagnosed with ischemic stroke in the anterior vascular territory (AVT) and posterior vascular territory (PVT). All the patients had venous blood collected at admission and 7 days after the onset of the cerebral ischemia in order to determine the plasma concentration of interleukin-1 beta. At the same time, an extracranial carotid ultrasound was performed. Results: The interleukin-1 beta collected at admission was positively correlated with the NIHSS at admission (Pearson index 0.424), and both measurements were correlated with carotid stenosis (Spearmen correlation index of 0.529 and 0.653, respectively). Conclusions: Interleukin-1 beta could be a reliable biomarker for stroke prognosis and the development of atherosclerotic lesions of the internal carotid.
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ISSN:1648-9144
1010-660X
1648-9144
DOI:10.3390/medicina59101790