Regulation of cardiac bradykinin B1- and B2-receptor mRNA in experimental ischemic, diabetic, and pressure-overload-induced cardiomyopathy

• Published in: International immunopharmacology Vol. 2; no. 13; pp. 1823 - 1832
• Main Authors: Spillmann, Frank, Altmann, Christine, Scheeler, Michael, Barbosa, Marcos, Westermann, Dirk, Schultheiss, Heinz-Peter, Walther, Thomas, Tschöpe, Carsten
• Format: Journal Article Conference Proceeding
• Language: English
• Published: Amsterdam Elsevier B.V 01.12.2002; Elsevier
• Subjects: Animals; Aortic banding; B1 receptor; B2 receptor; Biological and medical sciences; Blood Pressure - physiology; Bradykinin; Cardiology. Vascular system; Cardiopathies: etiologic forms (general aspects and miscellaneous); Diabetes mellitus; Diabetes Mellitus, Experimental - metabolism; Diabetes Mellitus, Experimental - physiopathology; Heart; Hypertrophy, Left Ventricular - metabolism; Hypertrophy, Left Ventricular - physiopathology; Male; Medical sciences; Myocardial infarction; Myocardial Infarction - metabolism; Myocardial Infarction - physiopathology; Pressure; Rats; Rats, Sprague-Dawley; Receptor, Bradykinin B1; Receptor, Bradykinin B2; Receptors, Bradykinin - biosynthesis; RNA, Messenger - analysis; Streptozotocin; Systole - physiology; Up-Regulation; Ventricular Function, Left - physiology; Myocardial infarction; Bradykinin; Diabetes mellitus; B2 receptor; Aortic banding; B1 receptor; Streptozotocin; Hypertension; Bradykinin receptor; Rat; Cardiomyopathy; Rodentia; Left coronary artery; Gene expression; Left ventricle; Vertebrata; Experimental disease; Mammalia; Ligature; Animal; Hypertrophy

Although kinins have been associated with the regulation of cardiovascular function in left ventricular hypertrophy (LVH) as a consequence of hypertension, myocardial infarction (MI), and/or diabetic cardiomyopathy, less is known about their receptor regulation under these conditions. We have theref...