Catalase activity is necessary for heat-shock recovery in Aspergillus nidulans germlings
To understand the molecular mechanisms induced by stress that contribute to the development of tolerance in eukaryotic cells, the filamentous fungus Aspergillus nidulans has been chosen as a model system. Here, the response of A. nidulans germlings to heat shock is reported. The heat treatment drama...
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| Published in | Microbiology (Society for General Microbiology) Vol. 145; no. 11; pp. 3229 - 3234 |
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| Main Authors | , , , , , , , |
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| Language | English |
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Soc General Microbiol
01.11.1999
Society for General Microbiology |
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| Abstract | To understand the molecular mechanisms induced by stress that contribute to the development of tolerance in eukaryotic cells, the filamentous fungus Aspergillus nidulans has been chosen as a model system. Here, the response of A. nidulans germlings to heat shock is reported. The heat treatment dramatically increased the concentration of trehalose and induced the accumulation of mannitol and mRNA from the catalase gene catA. Both mannitol and catalase function to protect cells from different reactive oxygen species. Treatment with hydrogen peroxide increased A. nidulans germling viability after heat shock whilst mutants deficient in catalase were more sensitive to a 50 degrees C heat exposure. It is concluded that the defence against the lethal effects of heat exposure can be correlated with the activity of the defence system against oxidative stress. |
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| AbstractList | To understand the molecular mechanisms induced by stress that contribute to the development of tolerance in eukaryotic cells, the filamentous fungus Aspergillus nidulans has been chosen as a model system. Here, the response of A. nidulans germlings to heat shock is reported. The heat treatment dramatically increased the concentration of trehalose and induced the accumulation of mannitol and mRNA from the catalase gene catA. Both mannitol and catalase function to protect cells from different reactive oxygen species. Treatment with hydrogen peroxide increased A. nidulans germling viability after heat shock whilst mutants deficient in catalase were more sensitive to a 50 degrees C heat exposure. It is concluded that the defence against the lethal effects of heat exposure can be correlated with the activity of the defence system against oxidative stress. To understand the molecular mechanisms induced by stress that contribute to the development of tolerance in eukaryotic cells, the filamentous fungus Aspergillus nidulans has been chosen as a model system. Here, the response of A. nidulans germlings to heat shock is reported. The heat treatment dramatically increased the concentration of trehalose and induced the accumulation of mannitol and mRNA from the catalase gene catA. Both mannitol and catalase function to protect cells from different reactive oxygen species. Treatment with hydrogen peroxide increased A. nidulans germling viability after heat shock whilst mutants deficient in catalase were more sensitive to a 50 degrees C heat exposure. It is concluded that the defence against the lethal effects of heat exposure can be correlated with the activity of the defence system against oxidative stress.To understand the molecular mechanisms induced by stress that contribute to the development of tolerance in eukaryotic cells, the filamentous fungus Aspergillus nidulans has been chosen as a model system. Here, the response of A. nidulans germlings to heat shock is reported. The heat treatment dramatically increased the concentration of trehalose and induced the accumulation of mannitol and mRNA from the catalase gene catA. Both mannitol and catalase function to protect cells from different reactive oxygen species. Treatment with hydrogen peroxide increased A. nidulans germling viability after heat shock whilst mutants deficient in catalase were more sensitive to a 50 degrees C heat exposure. It is concluded that the defence against the lethal effects of heat exposure can be correlated with the activity of the defence system against oxidative stress. Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo and Universidade de Franca, Av. do Café S/N, CEP 14040-903, Ribeirão Preto, São Paulo, Brazil 1 Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto, Universidade de São Paulo, São Paulo, Brazil 2 Instituto de Fisiologia Celular-UNAM, Mexico City, Mexico 3 Department of Microbiology, Molecular Biology, and Biochemistry, University of Idaho, Moscow, ID, USA 4 Author for correspondence: Gustavo H. Goldman. Tel: +55 16 6024280/81. Fax: +55 16 6331092/6024280. e-mail: ggoldman{at}usp.br To understand the molecular mechanisms induced by stress that contribute to the development of tolerance in eukaryotic cells, the filamentous fungus Aspergillus nidulans has been chosen as a model system. Here, the response of A. nidulans germlings to heat shock is reported. The heat treatment dramatically increased the concentration of trehalose and induced the accumulation of mannitol and mRNA from the catalase gene catA . Both mannitol and catalase function to protect cells from different reactive oxygen species. Treatment with hydrogen peroxide increased A. nidulans germling viability after heat shock whilst mutants deficient in catalase were more sensitive to a 50 °C heat exposure. It is concluded that the defence against the lethal effects of heat exposure can be correlated with the activity of the defence system against oxidative stress. Keywords: catalase, heat shock, stress tolerance, Aspergillus nidulans Abbreviations: ROS, reactive oxygen species |
| Author | Goldman, M.H.S Goldman, G.H Iyer, S Aguirre, J Terenzi, H.F Noventa-Jordao, M.A Couto, R.M Caplan, A |
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| Cites_doi | 10.1128/jb.179.10.3284-3292.1997 10.1111/j.1574-6968.1997.tb12639.x 10.1016/S0065-2660(08)60245-X 10.1128/MMBR.59.3.506-531.1995 10.1074/jbc.273.35.22480 10.1172/JCI108786 10.1099/13500872-140-12-3277 10.1073/pnas.83.21.8059 10.1016/0014-5793(94)01207-5 10.1128/JB.180.21.5733-5738.1998 10.1007/978-3-662-10367-8_19 10.1046/j.1365-2958.1996.403940.x 10.1099/00221287-142-4-937 10.1016/S0065-2660(08)60522-2 10.4049/jimmunol.156.10.3836 10.1128/jb.179.1.157-162.1997 10.1073/pnas.93.10.5116 10.1016/S0021-9258(18)98912-X 10.1021/ja00899a032 |
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| Keywords | Oxidative stress Trehalose Enzyme Gene expression Hydrogen Peroxides Fungi Resistance Peroxidases Catalase Aspergillus nidulans Thermal shock Mannitol Fungi Imperfecti Oxidoreductases Thallophyta |
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| References | Donnely (R6) 1994; 355 Navarro (R16) 1996; 29 Santoro (R19) 1997 Jorge (R9) 1997; 154 Scandalios (R20) 1990; 28 Navarro (R15) 1998; 180 Sweeley (R21) 1963; 85 Tauber (R22) 1977; 60 Thevelein (R23) 1996 Piper (R17) 1997 Wieser (R24) 1991; 266 Kawasaki (R11) 1997; 179 Brobst (R1) 1966; 43 Godon (R7) 1998; 273 Kafer (R10) 1977; 19 Sambrook (R18) 1989 Mager (R12) 1995; 59 Chaturvedi (R3) 1996b; 156 Moradas-Ferreira (R13) 1996; 19 Davidson (R5) 1996; 93 Jamieson (R8) 1994; 140 Morgan (R14) 1986; 83 Chaturvedi (R4) 1997; 179 Chaturvedi (R2) 1996a; 142 |
| References_xml | – volume: 179 start-page: 3284 year: 1997 ident: R11 article-title: Two divergent catalase genes are differentially regulated during Aspergillus nidulans development and oxidative stress publication-title: J Bacteriol doi: 10.1128/jb.179.10.3284-3292.1997 – volume: 154 start-page: 165 year: 1997 ident: R9 article-title: Trehalases and trehalose hydrolysis in fungi publication-title: FEMS Microbiol Lett doi: 10.1111/j.1574-6968.1997.tb12639.x – start-page: 171 year: 1997 ident: R19 article-title: Oxidative stress responses in the yeast publication-title: Yeast Stress Responses – volume: 19 start-page: 33 year: 1977 ident: R10 article-title: Meiotic and mitotic recombination in Aspergillus and its chromosomal aberrations publication-title: Adv Genet doi: 10.1016/S0065-2660(08)60245-X – volume: 59 start-page: 506 year: 1995 ident: R12 article-title: Stress-induced transcriptional activation publication-title: Microbiol Rev doi: 10.1128/MMBR.59.3.506-531.1995 – volume: 29 start-page: 352 year: 1996 ident: R16 article-title: catA, a new Aspergillus nidulans gene encoding a developmentally regulated catalase publication-title: Curr Genet – start-page: 75 year: 1997 ident: R17 article-title: The yeast heat shock response publication-title: Yeast Stress Responses – volume: 273 start-page: 22480 year: 1998 ident: R7 article-title: The H2O2 stimulon in Saccharomyces cerevisiae. publication-title: J Biol Chem doi: 10.1074/jbc.273.35.22480 – volume: 60 start-page: 374 year: 1977 ident: R22 article-title: Evidence for hydroxyl radical production by human neutrophils publication-title: J Clin Invest doi: 10.1172/JCI108786 – volume: 140 start-page: 3277 year: 1994 ident: R8 article-title: Analysis of Saccharomyces cerevisiae proteins induced by peroxide and superoxide stress publication-title: Microbiology doi: 10.1099/13500872-140-12-3277 – volume: 83 start-page: 8059 year: 1986 ident: R14 article-title: Hydrogen peroxide-inducible proteins in Salmonella typhimurium overlap with heat shock and other stress proteins publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.83.21.8059 – volume: 355 start-page: 201 year: 1994 ident: R6 article-title: Germinating conidiospores of Aspergillus amino acid auxotrophs are hypersensitive to heat shock, oxidative stress and DNA damage publication-title: FEBS Lett doi: 10.1016/0014-5793(94)01207-5 – volume: 180 start-page: 5733 year: 1998 ident: R15 article-title: Posttranscriptional control mediates cell type-specific localization of catalase A during Aspergillus nidulans development publication-title: J Bacteriol doi: 10.1128/JB.180.21.5733-5738.1998 – volume: 43 start-page: 35 year: 1966 ident: R1 article-title: Determination of some compounds in corn syrup by gas-liquid chromatography of the trimethylsilyl derivatives publication-title: Cereal Chem – start-page: 395 year: 1996 ident: R23 article-title: Regulation of trehalose metabolism and its relevance to cell growth and function publication-title: The Mycota III, Biochemistry and Molecular Biology doi: 10.1007/978-3-662-10367-8_19 – volume: 19 start-page: 651 year: 1996 ident: R13 article-title: The molecular defences against reactive oxygen species in yeast publication-title: Mol Microbiol doi: 10.1046/j.1365-2958.1996.403940.x – volume: 142 start-page: 937 year: 1996a ident: R2 article-title: Stress tolerance and pathogenic potential of a mannitol mutant of Cryptococcus neoformans. publication-title: Microbiology doi: 10.1099/00221287-142-4-937 – volume: 28 start-page: 1 year: 1990 ident: R20 article-title: Response of plant antioxidant defense genes to environmental stress publication-title: Adv Genet doi: 10.1016/S0065-2660(08)60522-2 – volume: 156 start-page: 3836 year: 1996b ident: R3 article-title: Oxidative killing of Cryptococcus neoformans by human neutrophils: evidence that fungal mannitol protects by scavenging reactive oxygen intermediates publication-title: J Immunol doi: 10.4049/jimmunol.156.10.3836 – volume-title: Molecular Cloning: a Laboratory Manual year: 1989 ident: R18 – volume: 179 start-page: 157 year: 1997 ident: R4 article-title: Expression of bacterial mtlD in Saccharomyces cerevisiae results in mannitol synthesis and protects a glycerol-defective mutant from high-salt and oxidative stress publication-title: J Bacteriol doi: 10.1128/jb.179.1.157-162.1997 – volume: 93 start-page: 5116 year: 1996 ident: R5 article-title: Oxidative stress is involved in heat-induced cell death in Saccharomyces cerevisiae. publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.93.10.5116 – volume: 266 start-page: 12406 year: 1991 ident: R24 article-title: Heat shock factor-independent heat control of transcription of the CTT1 gene encoding the cytosolic catalase T of Saccharomyces cerevisiae. publication-title: J Biol Chem doi: 10.1016/S0021-9258(18)98912-X – volume: 85 start-page: 2497 year: 1963 ident: R21 article-title: Gas-liquid chromatography of trimethylsilyl derivatives of sugars and related substances publication-title: J Am Chem Soc doi: 10.1021/ja00899a032 |
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| SubjectTerms | Action of physical and chemical agents Aspergillus nidulans Aspergillus nidulans - drug effects Aspergillus nidulans - enzymology Aspergillus nidulans - physiology Biological and medical sciences Blotting, Northern catA gene Catalase - genetics Catalase - metabolism Chromatography, Gas Fundamental and applied biological sciences. Psychology Fungal Proteins - genetics Fungal Proteins - metabolism Gene Deletion Heat-Shock Proteins - genetics Heat-Shock Proteins - metabolism hydrogen peroxide Hydrogen Peroxide - pharmacology mannitol Mannitol - metabolism Microbiology Mycology plant biochemistry plant physiology RNA, Fungal - analysis RNA, Messenger - analysis Time Factors Trehalose - metabolism |
| Title | Catalase activity is necessary for heat-shock recovery in Aspergillus nidulans germlings |
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