Fusobacterium nucleatum Potentiates Intestinal Tumorigenesis and Modulates the Tumor-Immune Microenvironment

• Published in: Cell host & microbe Vol. 14; no. 2; pp. 207 - 215
• Main Authors: Kostic, Aleksandar D., Chun, Eunyoung, Robertson, Lauren, Glickman, Jonathan N., Gallini, Carey Ann, Michaud, Monia, Clancy, Thomas E., Chung, Daniel C., Lochhead, Paul, Hold, Georgina L., El-Omar, Emad M., Brenner, Dean, Fuchs, Charles S., Meyerson, Matthew, Garrett, Wendy S.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 14.08.2013
• Subjects: adenoma; Adenoma - immunology; Adenoma - microbiology; Adenoma - pathology; animal models; Animals; bacteria; carcinogenesis; Carcinogenesis - immunology; carcinoma; colitis; colorectal neoplasms; Colorectal Neoplasms - immunology; Colorectal Neoplasms - microbiology; Colorectal Neoplasms - pathology; Cytokines - biosynthesis; Disease Models, Animal; enteritis; feces; Fusobacterium nucleatum; Fusobacterium nucleatum - immunology; Fusobacterium nucleatum - pathogenicity; Humans; intestinal microorganisms; Leukocytes - immunology; metagenomics; Mice; patients

Increasing evidence links the gut microbiota with colorectal cancer. Metagenomic analyses indicate that symbiotic Fusobacterium spp. are associated with human colorectal carcinoma, but whether this is an indirect or causal link remains unclear. We find that Fusobacterium spp. are enriched in human c...