Simultaneous determination of methylphenidate and ritalinic acid in hair using LC–MS/MS

• Published in: Forensic science international Vol. 294; pp. 183 - 188
• Main Authors: Jang, Moonhee, Kim, Jihyun, Shin, Ilchung, Kang, Seojin, Choi, Hyeyoung, Yang, Wonkyung
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier B.V 01.01.2019; Elsevier Limited
• Subjects: Accuracy; Acids; Attention deficit hyperactivity disorder; chemical species; Chromatography; Cocaine; detection limit; Forensic sciences; Hair; Hair analysis; liquid chromatography; Liquid chromatography-tandem mass spectrometry; Mass spectrometry; metabolites; methamphetamines; methanol; Methods; Methylphenidate; Prescription drugs; Ritalinic acid; Scientific imaging; tandem mass spectrometry; tetrahydrocannabinol; United States > US; Hair; Liquid chromatography-tandem mass spectrometry; Ritalinic acid; Methylphenidate

[Display omitted] •An LC–MS/MS method was developed to document methylphenidate use in hair specimens.•Target analytes were methylphenidate and its metabolite, ritalinic acid.•A simple sample preparation was carried out with a small amount of sample.•The method was successfully applied to authentic...