Role of Insulin in Placental Transport of Nutrients in Gestational Diabetes Mellitus

• Published in: Annals of nutrition and metabolism Vol. 70; no. 1; p. 16
• Main Authors: Ruiz-Palacios, María, Ruiz-Alcaraz, Antonio José, Sanchez-Campillo, María, Larqué, Elvira
• Format: Journal Article
• Language: English
• Published: Switzerland 01.01.2017
• Subjects: Birth Weight; Diabetes, Gestational - drug therapy; Female; Humans; Infant, Newborn; Insulin - administration & dosage; Insulin - metabolism; Placenta - drug effects; Placenta - metabolism; Pregnancy; Signal Transduction - physiology

Gestational diabetes mellitus (GDM) is associated with increased fetal adiposity, which may increase the risk of obesity in adulthood. The placenta has insulin receptors and maternal insulin can activate its signaling pathways, affecting the transport of nutrients to the fetus. However, the effects...