Break force and tensile strength relationships for curved faced tablets subject to diametrical compression

• Published in: International journal of pharmaceutics Vol. 442; no. 1-2; pp. 57 - 64
• Main Authors: Shang, C., Sinka, I.C., Jayaraman, B., Pan, J.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 14.02.2013
• Subjects: Break force; Cellulose - chemistry; Curved tablet; Drug Compounding; equations; Excipients - chemistry; Hardness; Models, Theoretical; Pharmaceutical tablet; Pressure; Tablets - chemistry; Tensile Strength; Curved tablet; Break force; Pharmaceutical tablet; Tensile strength

The break force of flat faced tablets subject to diametrical compression (often referred to as “hardness”) can be related to the tensile strength of the material using the Hertz contact theory. For curved tablets analytical solutions do not exist and an empirical equation developed by Pitt and Newto...