Break force and tensile strength relationships for curved faced tablets subject to diametrical compression

The break force of flat faced tablets subject to diametrical compression (often referred to as “hardness”) can be related to the tensile strength of the material using the Hertz contact theory. For curved tablets analytical solutions do not exist and an empirical equation developed by Pitt and Newto...

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Bibliographic Details
Published inInternational journal of pharmaceutics Vol. 442; no. 1-2; pp. 57 - 64
Main Authors Shang, C., Sinka, I.C., Jayaraman, B., Pan, J.
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 14.02.2013
Subjects
Break force
Cellulose - chemistry
Curved tablet
Drug Compounding
equations
Excipients - chemistry
Hardness
Models, Theoretical
Pharmaceutical tablet
Pressure
Tablets - chemistry
Tensile Strength
Curved tablet
Break force
Pharmaceutical tablet
Tensile strength
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Summary:The break force of flat faced tablets subject to diametrical compression (often referred to as “hardness”) can be related to the tensile strength of the material using the Hertz contact theory. For curved tablets analytical solutions do not exist and an empirical equation developed by Pitt and Newton (1988) is usually used. In this paper we measure the break force of curved faced tablets having a range of curvatures pressed at various compaction forces. An empirical equation is proposed to relate the break force of curved faced tablets to the material tensile strength. The proposed equation is simplified and reduced to a form that is consistent with developed by Hertz theory for flat faced tablets.
Bibliography:http://dx.doi.org/10.1016/j.ijpharm.2012.09.005
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0378-5173
1873-3476
1873-3476
DOI:10.1016/j.ijpharm.2012.09.005