Break force and tensile strength relationships for curved faced tablets subject to diametrical compression
The break force of flat faced tablets subject to diametrical compression (often referred to as “hardness”) can be related to the tensile strength of the material using the Hertz contact theory. For curved tablets analytical solutions do not exist and an empirical equation developed by Pitt and Newto...
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| Published in | International journal of pharmaceutics Vol. 442; no. 1-2; pp. 57 - 64 |
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| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
| Published |
Netherlands
Elsevier B.V
14.02.2013
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| Abstract | The break force of flat faced tablets subject to diametrical compression (often referred to as “hardness”) can be related to the tensile strength of the material using the Hertz contact theory. For curved tablets analytical solutions do not exist and an empirical equation developed by Pitt and Newton (1988) is usually used. In this paper we measure the break force of curved faced tablets having a range of curvatures pressed at various compaction forces. An empirical equation is proposed to relate the break force of curved faced tablets to the material tensile strength. The proposed equation is simplified and reduced to a form that is consistent with developed by Hertz theory for flat faced tablets. |
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| AbstractList | The break force of flat faced tablets subject to diametrical compression (often referred to as "hardness") can be related to the tensile strength of the material using the Hertz contact theory. For curved tablets analytical solutions do not exist and an empirical equation developed by Pitt and Newton (1988) is usually used. In this paper we measure the break force of curved faced tablets having a range of curvatures pressed at various compaction forces. An empirical equation is proposed to relate the break force of curved faced tablets to the material tensile strength. The proposed equation is simplified and reduced to a form that is consistent with developed by Hertz theory for flat faced tablets. The break force of flat faced tablets subject to diametrical compression (often referred to as "hardness") can be related to the tensile strength of the material using the Hertz contact theory. For curved tablets analytical solutions do not exist and an empirical equation developed by Pitt and Newton (1988) is usually used. In this paper we measure the break force of curved faced tablets having a range of curvatures pressed at various compaction forces. An empirical equation is proposed to relate the break force of curved faced tablets to the material tensile strength. The proposed equation is simplified and reduced to a form that is consistent with developed by Hertz theory for flat faced tablets.The break force of flat faced tablets subject to diametrical compression (often referred to as "hardness") can be related to the tensile strength of the material using the Hertz contact theory. For curved tablets analytical solutions do not exist and an empirical equation developed by Pitt and Newton (1988) is usually used. In this paper we measure the break force of curved faced tablets having a range of curvatures pressed at various compaction forces. An empirical equation is proposed to relate the break force of curved faced tablets to the material tensile strength. The proposed equation is simplified and reduced to a form that is consistent with developed by Hertz theory for flat faced tablets. |
| Author | Sinka, I.C. Jayaraman, B. Pan, J. Shang, C. |
| Author_xml | – sequence: 1 givenname: C. surname: Shang fullname: Shang, C. – sequence: 2 givenname: I.C. surname: Sinka fullname: Sinka, I.C. email: ics4@le.ac.uk – sequence: 3 givenname: B. surname: Jayaraman fullname: Jayaraman, B. – sequence: 4 givenname: J. surname: Pan fullname: Pan, J. |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/22975309$$D View this record in MEDLINE/PubMed |
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| Keywords | Curved tablet Break force Pharmaceutical tablet Tensile strength |
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| Snippet | The break force of flat faced tablets subject to diametrical compression (often referred to as “hardness”) can be related to the tensile strength of the... The break force of flat faced tablets subject to diametrical compression (often referred to as "hardness") can be related to the tensile strength of the... |
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| SubjectTerms | Break force Cellulose - chemistry Curved tablet Drug Compounding equations Excipients - chemistry Hardness Models, Theoretical Pharmaceutical tablet Pressure Tablets - chemistry Tensile Strength |
| Title | Break force and tensile strength relationships for curved faced tablets subject to diametrical compression |
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