Immunohistochemical detection of Lp25 and LipL32 proteins in skeletal and cardiac muscles of fatal human leptospirosis

• Published in: Revista do Instituto de Medicina Tropical de São Paulo Vol. 62; pp. e85 - 10
• Main Authors: Iglezias, Silvia D'Andretta, Abreu, Patrícia Antonia Estima, Kanamura, Cristina, Magaldi, Antonio José, Seguro, Antonio Carlos, Brito, Thales De
• Format: Journal Article
• Language: English
• Published: Brazil Instituto de Medicina Tropical de Sao Paulo 01.01.2020; Instituto de Medicina Tropical; Instituto de Medicina Tropical de São Paulo; Universidade de São Paulo (USP)
• Subjects: Acute Kidney Injury - microbiology; Acute Kidney Injury - pathology; Animals; Bacterial Outer Membrane Proteins - genetics; Bacterial Outer Membrane Proteins - metabolism; Female; Genes, Bacterial; Guinea Pigs; Humans; Kidney - pathology; Leptospira; Leptospira - genetics; Leptospira - metabolism; Leptospirosis; Leptospirosis - complications; Leptospirosis - metabolism; LipL32; Lipoproteins - genetics; Lipoproteins - metabolism; Lp25; Male; Middle Aged; Muscles - pathology; Myocardium - pathology; Original; Rhabdomyolysis; TROPICAL MEDICINE; Weil’s disease; Leptospirosis; Lp25; Rhabdomyolysis; Weil’s disease; LipL32; Leptospira

Leptospirosis is an acute infection caused by pathogenic species of the genus Leptospira, which affects humans and animals in all world. In severe forms of the disease, kidneys, liver and lungs are the main affected organs, resulting in acute kidney injury, jaundice and pulmonary hemorrhage. Previou...