Norspermidine Is Not a Self-Produced Trigger for Biofilm Disassembly

• Published in: Cell Vol. 156; no. 4; pp. 844 - 854
• Main Authors: Hobley, Laura, Kim, Sok Ho, Maezato, Yukari, Wyllie, Susan, Fairlamb, Alan H., Stanley-Wall, Nicola R., Michael, Anthony J.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 13.02.2014; Cell Press
• Subjects: Amino Acid Sequence; Bacillus subtilis; Bacillus subtilis - growth & development; Bacillus subtilis - physiology; Biofilms - growth & development; gamma-Aminobutyric Acid - metabolism; Matters Arising; Molecular Sequence Data; Plankton - growth & development; Sequence Alignment; Spermidine - analogs & derivatives; Spermidine - biosynthesis; Spermidine - metabolism; Spermidine - physiology; Vibrio cholerae; Vibrio cholerae - physiology

Formation of Bacillus subtilis biofilms, consisting of cells encapsulated within an extracellular matrix of exopolysaccharide and protein, requires the polyamine spermidine. A recent study reported that (1) related polyamine norspermidine is synthesized by B. subtilis using the equivalent of the Vib...