Metabolic syndrome alters expression of insulin signaling-related genes in swine mesenchymal stem cells

• Published in: Gene Vol. 644; pp. 101 - 106
• Main Authors: Conley, Sabena M., Zhu, Xiang-Yang, Eirin, Alfonso, Tang, Hui, Lerman, Amir, van Wijnen, Andre J., Lerman, Lilach O.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 20.02.2018
• Subjects: abdominal fat; adipocytes; Adipose Tissue - metabolism; Animals; Body Mass Index; calcium signaling; Calcium Signaling - physiology; Cell Differentiation - physiology; diet; Diet - methods; Down-Regulation - physiology; gene expression; gene ontology; genes; glucose; Glucose - metabolism; inflammation; Insulin; Insulin - metabolism; insulin resistance; Insulin Resistance - physiology; kidney diseases; Mesenchymal stem cells; Mesenchymal Stem Cells - metabolism; messenger RNA; Metabolic syndrome; Metabolic Syndrome - metabolism; metabolism; mRNA; muscles; Obesity - metabolism; patients; peptides; RNA, Messenger - metabolism; stem cells; stromal cells; Swine; transcription (genetics); Transcriptome - physiology; Up-Regulation - physiology; IR; mRNA; PPARα; Metabolic syndrome; Insulin; ECM; MetS; RNA-seq; B3GNT3; S1PR3; MSC; CKD; Mesenchymal stem cells
• ISSN: 0378-1119; 1879-0038; 1879-0038
• DOI: 10.1016/j.gene.2017.10.086

Metabolic syndrome (MetS) is associated with insulin resistance (IR) and impaired glucose metabolism in muscle, fat, and other cells, and may induce inflammation and vascular remodeling. Endogenous reparative systems, including adipose tissue-derived mesenchymal stem/stromal cells (MSC), are respons...