Anakinra Therapy for Non-cancer Inflammatory Diseases

• Published in: Frontiers in pharmacology Vol. 9; p. 1157
• Main Authors: Cavalli, Giulio, Dinarello, Charles A
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 06.11.2018
• Subjects: IL-1α; IL-1β; inflammation; interleukin 1; Pharmacology; rheumatology; rheumatology; IL-1β; inflammation; IL-1α; interleukin 1

Interleukin-1 (IL-1) is the prototypical inflammatory cytokine: two distinct ligands (IL-1α and IL-1β) bind the IL-1 type 1 receptor (IL-1R1) and induce a myriad of secondary inflammatory mediators, including prostaglandins, cytokines, and chemokines. IL-1α is constitutively present in endothelial a...