Yi-Zhi-Fang-Dai Formula Exerts a Protective Effect on the Injury of Tight Junction Scaffold Proteins in Vitro and in Vivo by Mediating Autophagy through Regulation of the RAGE/CaMKKβ/AMPK/mTOR Pathway

• Published in: Biological & pharmaceutical bulletin Vol. 43; no. 12; pp. 1847 - 1858
• Main Authors: Chan, Yuanjin, Chen, Wenjing, Chen, Yanjie, Lv, Zhongkuan, Wan, Wenbin, Li, Yaming, Zhang, Chunyan
• Format: Journal Article
• Language: English
• Published: Tokyo The Pharmaceutical Society of Japan 01.12.2020; Japan Science and Technology Agency
• Subjects: Advanced glycosylation end products; Alzheimer's disease; AMP; AMP-activated protein kinase; Autophagy; Blood-brain barrier; Ca2+/calmodulin-dependent protein kinase; Calcium (intracellular); Calcium-binding protein; Calmodulin; Cognition & reasoning; Cognitive ability; Gene expression; Glycosylation; Kinases; Neurodegeneration; Neurodegenerative diseases; Phagocytosis; Presenilin 1; Proteins; Rapamycin; receptor for advanced glycation end product (RAGE); siRNA; tight junction; TOR protein; Toxicity; Transcription; Transgenic mice; Zonula occludens-1 protein; β-Amyloid

Alzheimer’s disease (AD) is a chronic neurodegeneration disease that is closely related to the abnormal tight junction scaffold proteins (TJ) proteins of the blood–brain barrier (BBB). Recently, Yi-Zhi-Fang-Dai Formula (YZFDF) had exerted a neuronal protective effect against amyloid peptide (Aβ) tox...