Circadian temperature and melatonin rhythms, sleep, and neurobehavioral function in humans living on a 20-h day
Circadian, Neuroendocrine and Sleep Disorders Section, Division of Endocrinology, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115 The interaction of homeostatic and circadian processes in the regulation of waking neurobehavioral funct...
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| Published in | American journal of physiology. Regulatory, integrative and comparative physiology Vol. 277; no. 4; pp. 1152 - R1163 |
|---|---|
| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
01.10.1999
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| Subjects | |
| Online Access | Get full text |
| ISSN | 0363-6119 0002-9513 1522-1490 |
| DOI | 10.1152/ajpregu.1999.277.4.r1152 |
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| Abstract | Circadian, Neuroendocrine and Sleep Disorders Section, Division of
Endocrinology, Department of Medicine, Brigham and Women's
Hospital and Harvard Medical School, Boston, Massachusetts 02115
The interaction of homeostatic and
circadian processes in the regulation of waking neurobehavioral
functions and sleep was studied in six healthy young subjects. Subjects
were scheduled to 15-24 repetitions of a 20-h rest/activity cycle,
resulting in desynchrony between the sleep-wake cycle and the circadian rhythms of body temperature and melatonin. The circadian components of
cognitive throughput, short-term memory, alertness, psychomotor vigilance, and sleep disruption were at peak levels near the
temperature maximum, shortly before melatonin secretion onset. These
measures exhibited their circadian nadir at or shortly after the
temperature minimum, which in turn was shortly after the melatonin
maximum. Neurobehavioral measures showed impairment toward the end of
the 13-h 20-min scheduled wake episodes. This wake-dependent
deterioration of neurobehavioral functions can be offset by the
circadian drive for wakefulness, which peaks in the latter half of the
habitual waking day during entrainment. The data demonstrate the
exquisite sensitivity of many neurobehavioral functions to circadian
phase and the accumulation of homeostatic drive for sleep.
circadian rhythms; performance; body temperature; alertness; memory |
|---|---|
| AbstractList | The interaction of homeostatic and circadian processes in the regulation of waking neurobehavioral functions and sleep was studied in six healthy young subjects. Subjects were scheduled to 15–24 repetitions of a 20-h rest/activity cycle, resulting in desynchrony between the sleep-wake cycle and the circadian rhythms of body temperature and melatonin. The circadian components of cognitive throughput, short-term memory, alertness, psychomotor vigilance, and sleep disruption were at peak levels near the temperature maximum, shortly before melatonin secretion onset. These measures exhibited their circadian nadir at or shortly after the temperature minimum, which in turn was shortly after the melatonin maximum. Neurobehavioral measures showed impairment toward the end of the 13-h 20-min scheduled wake episodes. This wake-dependent deterioration of neurobehavioral functions can be offset by the circadian drive for wakefulness, which peaks in the latter half of the habitual waking day during entrainment. The data demonstrate the exquisite sensitivity of many neurobehavioral functions to circadian phase and the accumulation of homeostatic drive for sleep. Circadian, Neuroendocrine and Sleep Disorders Section, Division of Endocrinology, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115 The interaction of homeostatic and circadian processes in the regulation of waking neurobehavioral functions and sleep was studied in six healthy young subjects. Subjects were scheduled to 15-24 repetitions of a 20-h rest/activity cycle, resulting in desynchrony between the sleep-wake cycle and the circadian rhythms of body temperature and melatonin. The circadian components of cognitive throughput, short-term memory, alertness, psychomotor vigilance, and sleep disruption were at peak levels near the temperature maximum, shortly before melatonin secretion onset. These measures exhibited their circadian nadir at or shortly after the temperature minimum, which in turn was shortly after the melatonin maximum. Neurobehavioral measures showed impairment toward the end of the 13-h 20-min scheduled wake episodes. This wake-dependent deterioration of neurobehavioral functions can be offset by the circadian drive for wakefulness, which peaks in the latter half of the habitual waking day during entrainment. The data demonstrate the exquisite sensitivity of many neurobehavioral functions to circadian phase and the accumulation of homeostatic drive for sleep. circadian rhythms; performance; body temperature; alertness; memory |
| Author | Czeisler, Charles A Wyatt, James K Dijk, Derk-Jan Cecco, Angela Ritz-De |
| Author_xml | – sequence: 1 fullname: Wyatt, James K – sequence: 2 fullname: Cecco, Angela Ritz-De – sequence: 3 fullname: Czeisler, Charles A – sequence: 4 fullname: Dijk, Derk-Jan |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/10516257$$D View this record in MEDLINE/PubMed |
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Endocrinology, Department of Medicine, Brigham and Women's
Hospital and Harvard Medical... The interaction of homeostatic and circadian processes in the regulation of waking neurobehavioral functions and sleep was studied in six healthy young... |
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| SubjectTerms | Adult Behavior - physiology Body Temperature - physiology Circadian Rhythm Female Humans Male Melatonin - blood Nervous System Physiological Phenomena Photoperiod Sleep - physiology Sleep Stages - physiology Wakefulness - physiology |
| Title | Circadian temperature and melatonin rhythms, sleep, and neurobehavioral function in humans living on a 20-h day |
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