Profiling SARS-CoV-2 HLA-I peptidome reveals T cell epitopes from out-of-frame ORFs - Weingarten-Gabbay, Shira; Klaeger, Susan; Sarkizova, Siranush; Pearlman, Leah R.; Chen, Da-Yuan; Gallagher, Kathleen M.E.; Bauer, Matthew R.; Taylor, Hannah B.; Dunn, W. Augustine; Tarr, Christina; Sidney, John; Rachimi, Suzanna; et al. (Cell, 2021)
Keywords: A549 Cells; Alleles; Amino Acid Sequence; animal models; Animals; Antigen Presentation - immunology; cell-mediated immunity; coronavirus; COVID-19 - immunology; COVID-19 - virology; COVID-19 infection; epitopes; Epitopes, T-Lymphocyte - immunology; Female; HEK293 Cells; Histocompatibility Antigens Class I - immunology; HLA antigens; HLA Class I; Humans; immunogenicity; Kinetics; Male; mass spectrometry; Mice; nucleocapsid; Open Reading Frames - genetics; out-of-frame ORF immunopeptidomics; peptides; Peptides - chemistry; Peptides - immunology; Proteome - immunology; SARS-CoV-2; SARS-CoV-2 - immunology; Severe acute respiratory syndrome coronavirus 2; T Cell response; T-lymphocytes; T-Lymphocytes - immunology; vaccine development; viral infection; HLA Class I; SARS-CoV-2; out-of-frame ORF immunopeptidomics; viral infection; T Cell response; coronavirus; immunogenicity