U-shaped relationship between serum uric acid levels and intrarenal hemodynamic parameters in healthy subjects

• Published in: American journal of physiology. Renal physiology Vol. 312; no. 6; pp. F992 - F997
• Main Authors: Uedono, Hideki, Tsuda, Akihiro, Ishimura, Eiji, Nakatani, Shinya, Kurajoh, Masafumi, Mori, Katsuhito, Uchida, Junji, Emoto, Masanori, Nakatani, Tatsuya, Inaba, Masaaki
• Format: Journal Article
• Language: English
• Published: United States American Physiological Society 01.06.2017
• Subjects: Adult; Aged; Biomarkers - blood; Female; Glomerular Filtration Rate; Healthy Volunteers; Hemodynamics; Humans; Hyperuricemia; Hyperuricemia - blood; Hyperuricemia - physiopathology; Infusions, Intravenous; Inulin; Inulin - administration & dosage; Inulin - metabolism; Kidney - blood supply; Kidneys; Male; Middle Aged; Models, Biological; Multiple regression analysis; p-Aminohippuric Acid - administration & dosage; p-Aminohippuric Acid - metabolism; Regression Analysis; Renal Circulation; Renal function; Renal Plasma Flow; Sensory neurons; Uric acid; Uric Acid - blood; Variables; inulin clearance; para-aminohippurate clearance; renal hemodynamics

Hyperuricemia has been reported to affect renal hemodynamics. In a recent study, both low and high levels of serum uric acid (SUA) were found to be associated with loss of kidney function. The goal of this study was to evaluate the relationship between SUA levels and intrarenal hemodynamic parameter...