Hypothyroidism as an immune-related adverse event caused by atezolizumab in a patient with muscle spasms: a case report

• Published in: Respiratory medicine case reports Vol. 36; p. 101585
• Main Authors: Kawataki, Masanori, Nakanishi, Yosuke, Yokoyama, Toshihide, Ishida, Tadashi
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.01.2022; Elsevier
• Subjects: Case Report; hyperCKemia; Hyperthyroidism; Hypothyroidism; Immune checkpoint inhibitors (ICIs); Immune-related adverse events (irAEs); Muscle cramps; Immune-related adverse events (irAEs); Immune checkpoint inhibitors (ICIs); hyperCKemia; Hyperthyroidism; ICIs; TSH; Hypothyroidism; TPO Ab; Muscle cramps; TRAb; nab-PTX; irAEs; CPK; TRAb, Antithyrotropin receptor antibody; TSH, thyroid stimulating hormone; ICIs, immune checkpoint inhibitors; nab-PTX, nab-paclitaxel; CPK, creatine phosphokinase; irAEs, immune-related adverse events; TPO Ab, Antithyroperoxidase antibody

A 60-year-old man with a history of 4 cycles of atezolizumab treatment for non-small cell lung cancer presented to our hospital with a chief complaint of proximal muscle-dominant spasms. Blood tests showed elevated creatine phosphokinase (CPK) of 8450 U/L and hypothyroidism. There was little improve...