Stereoselective Metabolism by Human Liver CYP Enzymes of A Substituted Benzimidazole

• Published in: Drug metabolism and disposition Vol. 28; no. 1; pp. 58 - 64
• Main Authors: Äbelö, Angela, Andersson, Tommy B., Bredberg, Ulf, Skånberg, Inger, Weidolf, Lars
• Format: Journal Article
• Language: English
• Published: Bethesda, MD Elsevier Inc 01.01.2000; American Society for Pharmacology and Experimental Therapeutics
• Subjects: Anti-Ulcer Agents - chemistry; Anti-Ulcer Agents - metabolism; Aryl Hydrocarbon Hydroxylases; Benzimidazole; Biological and medical sciences; Cells, Cultured; Chromatography, Liquid; Cytochrome P-450 CYP2C19; Cytochrome P-450 Enzyme System - metabolism; Digestive system; H-259/31; Humans; Medical sciences; Microsomes, Liver - enzymology; Mixed Function Oxygenases - metabolism; Omeprazole - analogs & derivatives; Omeprazole - metabolism; Pharmacology. Drug treatments; Stereoisomerism; Substrate Specificity; EM; CYP; DMSO; PM; LC; AUC; Human; Omeprazole; Stereoselectivity; Benzimidazole derivatives; Analog; Enantiomer; Liver; Structure metabolism relation; Metabolism; In vitro

H 259/31 is a substituted benzimidazole developed as a structural analog of omeprazole. Metabolites of H 259/31 formed in human liver microsomes were identified by using the synthetic reference compounds and liquid chromatography/mass spectrometry. The predominant metabolic pathways found include ox...