Dysfunction of Astrocyte Connexins 30 and 43 in Dorsal Lateral Prefrontal Cortex of Suicide Completers

• Published in: Biological psychiatry (1969) Vol. 70; no. 4; pp. 312 - 319
• Main Authors: Ernst, Carl, Nagy, Corina, Kim, Sangyheon, Yang, Jennie P, Deng, Xiaoming, Hellstrom, Ian C, Choi, Kwang Ho, Gershenfeld, Howard, Meaney, Michael J, Turecki, Gustavo
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 15.08.2011
• Subjects: Adult; Animals; Astrocyte; Astrocytes - metabolism; Cell Line, Transformed; connexin; Connexin 30; Connexin 43 - genetics; Connexin 43 - metabolism; Connexins - genetics; Connexins - metabolism; Electrophoretic Mobility Shift Assay; Female; Gene Expression Regulation - genetics; genetics; Humans; Male; Microarray Analysis - methods; Middle Aged; prefrontal cortex; Prefrontal Cortex - pathology; Protein Binding - genetics; Psychiatry; Quebec - ethnology; Rats; RNA, Small Interfering - genetics; RNA, Small Interfering - metabolism; Sox9; SOX9 Transcription Factor - genetics; SOX9 Transcription Factor - metabolism; Suicide; Time Factors; Transfection - methods; Sox9; genetics; Astrocyte; prefrontal cortex; connexin; suicide

Background Suicide is an important public health problem that results from the interaction of both psychosocial and biological factors. Although it is known that particular neurobiological processes underlie suicidal ideation and behavior, there still remains limited knowledge about the specific fac...