Total synthesis and anticancer activity of a cyclic heptapeptide from marine sponge using water soluble peptide coupling agent EDC

• Published in: Arabian journal of chemistry Vol. 12; no. 8; pp. 2782 - 2787
• Main Authors: Anand, Mohanam, Alagar, Muthukaruppan, Ranjitha, J., Selvaraj, Vaithialingam
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01.12.2019; Elsevier
• Subjects: Anticancer activity; Euryjanicin A – cyclic heptapeptide; Marine natural product; Solution phase synthesis; Euryjanicin A – cyclic heptapeptide; Marine natural product; Solution phase synthesis; Anticancer activity

Present investigation comprises of synthesis of a novel proline containing cyclic heptapeptide – Euryjanicin A, which was previously isolated from the marine sponge – Prosuberites laughlini. Naturally isolated cyclic heptapeptide was synthesized using solution phase peptide technique. All the coupli...