Regulation of matrix metalloproteinase-3 gene expression in inflammation: A molecular study

• Published in: Journal of conservative dentistry Vol. 21; no. 6; pp. 592 - 596
• Main Authors: Teja, Kavalipurapu, Ramesh, Sindhu, Priya, Vishnu
• Format: Journal Article
• Language: English
• Published: India Wolters Kluwer India Pvt. Ltd 01.11.2018; Medknow Publications and Media Pvt. Ltd; Medknow Publications & Media Pvt. Ltd; Medknow Publications & Media Pvt Ltd
• Subjects: Biochemistry; Cell lines; Cellular signal transduction; Densitometry; Dentin; Electrophoresis; Enzymes; Ethidium bromide; Extracellular matrix; Gene expression; Genes; Glyceraldehyde-3-phosphate dehydrogenase; Inflammation; Inflammatory diseases; Lipopolysaccharides; Macrophages; Matrix metalloproteinase; Metalloproteinase; Metalloproteins; Mitogens; Monosaccharides; Original; Pathology; Phosphates; Physiology; Polymerase chain reaction; Primers; Protein kinase; Protein kinases; RNA; Statistical analysis; Stromelysin 1; real-time-polymerase chain reactor; pulpitis; periapical abscess RAW 264-7 cell lines; Matrix metalloproteinase-3 gene

Introduction: Matrix metalloproteinases (MMPs) play a significant role in the efficient tissue turnover and remodeling. This study focuses on the regulation of the MMPs by the protein kinases at the level of gene expression and their signaling pathways. Materials and Methods: Lipopolysaccharide-indu...