Impact of age and body size on inter-individual variation in measures of lipid metabolism: influence of gender and apolipoprotein E genotype

• Published in: Clinical genetics Vol. 57; no. 1; pp. 35 - 47
• Main Authors: Lussier-Cacan, S, Bolduc, A, Xhignesse, M, Niyonsenga, T, Connelly, PW, Sing, CF
• Format: Journal Article
• Language: English
• Published: Copenhagen Munksgaard International Publishers 01.01.2000; Blackwell
• Subjects: Adolescent; Adult; Age Factors; Aged; Analytical, structural and metabolic biochemistry; Apo E polymorphism; Apolipoprotein A-I - blood; Apolipoprotein A-I - genetics; Apolipoproteins B - blood; Apolipoproteins B - genetics; Apolipoproteins E - genetics; Biological and medical sciences; Body Height; Body Mass Index; Cholesterol - blood; Cholesterol - genetics; Cholesterol, HDL - blood; Cholesterol, HDL - genetics; Cholesterol, VLDL - blood; Cholesterol, VLDL - genetics; context-dependency; Female; Fundamental and applied biological sciences. Psychology; gender-specificity; Genetic Variation; Genotype; Humans; Lipid Metabolism; Lipids; Male; Middle Aged; Miscellaneous; Other biological molecules; Phenotype; plasma lipoproteins; Polymorphism, Genetic; Protein Isoforms; Regression Analysis; Sex Factors; Triglycerides - blood; Triglycerides - genetics; Human; Exploration; Genotype; Lipids; Metabolism; Genetic determinism; Phenotype; Gene; Apolipoprotein E; Body size; Interindividual comparison; Environmental effect; Age

This study was undertaken in 1695 adult subjects (870 women and 825 men) in order to further document the complexity of the influence of the apolipoprotein (apo) E genotypes on the mean levels and intragenotypic variability of seven measures of lipid metabolism. In addition, the statistical relation...