Aberrant DNA methylation imprints in aborted bovine clones

• Published in: Molecular reproduction and development Vol. 75; no. 4; pp. 598 - 607
• Main Authors: Liu, Jing-He, Yin, Shen, Xiong, Bo, Hou, Yi, Chen, Da-Yuan, Sun, Qing-Yuan
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.04.2008; Wiley-Liss
• Subjects: Abortion, Spontaneous - genetics; Animals; Base Sequence; Biological and medical sciences; Cattle; Cloning, Organism; cow; DNA Methylation; Embryology: invertebrates and vertebrates. Teratology; epigenetic reprogramming; Fundamental and applied biological sciences. Psychology; Genomic Imprinting; methylation imprint; Molecular embryology; Molecular Sequence Data; Monoamine Oxidase - genetics; Nuclear Transfer Techniques; Promoter Regions, Genetic; RNA, Long Noncoding; RNA, Untranslated - genetics; Sequence Analysis, DNA - methods; somatic cell nuclear transfer; Ox; Somatic cell; epigenetic reprogramming; cow; Gene expression; Abortion; Genomic imprinting; somatic cell nuclear transfer; Vertebrata; Mammalia; Animal; DNA; Epigenetics; Artiodactyla; Molecular cloning; Methylation; Ungulata; methylation imprint

Genomic imprinting plays a very important role during development and its abnormality may heavily undermine the developmental potential of bovine embryos. Because of limited resources of the cow genome, bovine genomic imprinting, both in normal development and in somatic cell nuclear transfer (SCNT)...