Subcortical infarcts, Alzheimer's disease pathology, and memory function in older persons

• Published in: Annals of neurology Vol. 62; no. 1; pp. 59 - 66
• Main Authors: Schneider, Julie A., Boyle, Patricia A., Arvanitakis, Zoe, Bienias, Julia L., Bennett, David A.
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.07.2007; Willey-Liss
• Subjects: Aged, 80 and over; Alzheimer Disease - pathology; Alzheimer Disease - physiopathology; Biological and medical sciences; Brain - pathology; Cerebral Infarction - pathology; Cerebral Infarction - physiopathology; Cohort Studies; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases; Female; Geriatric Assessment; Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy; Humans; Male; Medical sciences; Memory - physiology; Nervous system (semeiology, syndromes); Neurology; Neuropsychological Tests; Regression Analysis; Anatomic pathology; Nervous system diseases; Infarct; Alzheimer disease; Central nervous system disease; Degenerative disease; Memory function; Subcortex; Cerebral disorder
• ISSN: 0364-5134; 1531-8249
• DOI: 10.1002/ana.21142

Objective Examine the effects of subcortical infarcts with Alzheimer's disease (AD) pathology on dementia, episodic memory, and other cognitive abilities in older persons. Methods Participants included 148 autopsied subjects of the Rush Memory and Aging Project (mean age, 88.0 years), a longitu...