Lipid rafts as signaling hubs in cancer cell survival/death and invasion: implications in tumor progression and therapy

• Published in: Journal of lipid research Vol. 61; no. 5; pp. 611 - 635
• Main Authors: Mollinedo, Faustino, Gajate, Consuelo
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.05.2020; Elsevier
• Subjects: cholesterol • cholesterol-rich membrane domains • IGF system • PI3K/AKT signaling • Fas/CD95 • death receptor • CASMER • raft targeting; cholesterol • cholesterol-rich membrane domains • IGF system • PI3K/AKT signaling • Fas/CD95 • death receptor • CASMER • raft targeting

Cholesterol/sphingolipid-rich membrane domains, known as lipid rafts or membrane rafts, play a critical role in the compartmentalization of signaling pathways. Physical segregation of proteins in lipid rafts may modulate the accessibility of proteins to regulatory or effector molecules. Thus, lipid...