Determination of ketamine, norketamine and dehydronorketamine in urine by hollow-fiber liquid-phase microextraction using an essential oil as supported liquid membrane

• Published in: Forensic science international Vol. 243; pp. 47 - 54
• Main Authors: Bairros, André Valle de, Lanaro, Rafael, Almeida, Rafael Menck de, Yonamine, Mauricio
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier Ireland Ltd 01.10.2014; Elsevier Limited
• Subjects: Accuracy; Analytical chemistry; Anesthetics, Dissociative - urine; Anhydrides; Chromatography; Essential oils; Eucalyptus; Extraction; Fibers; Forensic sciences; Forensic Toxicology - methods; Gas Chromatography-Mass Spectrometry; Hafnium; Hollow fiber–liquid phase microextraction; Humans; Hydrochloric Acid; Ketamine; Ketamine - analogs & derivatives; Ketamine - urine; Limit of Detection; Liquid membranes; Liquid Phase Microextraction - methods; Mass spectrometry; Metabolites; Methods; Offices; Pathology; Plant Oils; Urine; Urine; Ketamine; Essential oils; Gas chromatography–mass spectrometry; Hollow fiber–liquid phase microextraction

Abstract Here, we present a method for the determination of ketamine (KT) and its main metabolites, norketamine (NK) and dehydronorketamine (DHNK) in urine samples by using hollow-fiber liquid-phase microextraction (HF–LPME) in the three-phase mode. The fiber pores were filled with eucalyptus essent...