The Central Role of the F-Actin Surface in Myosin Force Generation

• Published in: Biology (Basel, Switzerland) Vol. 10; no. 12; p. 1221
• Main Authors: Doran, Matthew H, Lehman, William
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 23.11.2021; MDPI
• Subjects: Actin; actin-binding proteins; Adenosine triphosphatase; Amino acids; Binding sites; Cell size; Electron microscopy; Enzymes; Filaments; force production; Hydrolysis; Isoforms; Kinases; molecular motor; Motor activity; Myosin; Myosin ATPase; Polymerization; Proteins; Review; Somatic cells; tropomyosin; myosin; actin; tropomyosin; force production; actin-binding proteins; molecular motor

Actin is one of the most abundant and versatile proteins in eukaryotic cells. As discussed in many contributions to this Special Issue, its transition from a monomeric G-actin to a filamentous F-actin form plays a critical role in a variety of cellular processes, including control of cell shape and...