An AMPK–caspase-6 axis controls liver damage in nonalcoholic steatohepatitis - Zhao, Peng; Sun, Xiaoli; Chaggan, Cynthia; Liao, Zhongji; in Wong, Kai; He, Feng; Singh, Seema; Loomba, Rohit; Karin, Michael; Witztum, Joseph L.; Saltiel, Alan R. (Science (American Association for the Advancement of Science), 2020)
Keywords: Activation; Adenosine; Adenosine kinase; Adenosine monophosphate; AMP; AMP-Activated Protein Kinases - genetics; AMP-Activated Protein Kinases - metabolism; Animal models; Animals; Apoptosis; Apoptosis - genetics; Caspase 3 - metabolism; Caspase 6 - metabolism; Caspase 7 - metabolism; Caspase Inhibitors - pharmacology; Caspase Inhibitors - therapeutic use; Caspase-3; Caspase-6; Cell death; Cytochrome c; Cytochromes; Damage; Disease control; Enzyme Activation; Fibrosis; Hepatocytes; Hepatocytes - enzymology; Hepatocytes - pathology; Humans; Inhibition; Kinases; Liver; Liver - enzymology; Liver - pathology; Liver diseases; Mice; Mice, Knockout; Mortality; Non-alcoholic Fatty Liver Disease - drug therapy; Non-alcoholic Fatty Liver Disease - enzymology; Non-alcoholic Fatty Liver Disease - pathology; Phosphates; Phosphorylation; Protein kinase; Proteins; Therapeutic applications