In Vitro and In Vivo Evaluations of Cytochrome P450 1A2 Interactions with Duloxetine - Lobo, Evelyn D.; Bergstrom, Richard F.; Reddy, Shobha; Quinlan, Tonya; Chappell, Jill; Hong, Quan; Ring, Barbara; Knadler, Mary Pat (Clinical pharmacokinetics, 2008)
Keywords: Administration, Oral; Adult; Area Under Curve; Biological and medical sciences; Biological Availability; Cross-Over Studies; Cytochrome P-450 CYP1A2 - drug effects; Cytochrome P-450 CYP1A2 - metabolism; Drug Interactions; Duloxetine Hydrochloride; Female; Fluvoxamine - pharmacology; General pharmacology; Humans; Infusions, Intravenous; Internal Medicine; Male; Medical sciences; Medicine; Medicine & Public Health; Microsomes, Liver - metabolism; Middle Aged; Original Research Article; Pharmacokinetics. Pharmacogenetics. Drug-receptor interactions; Pharmacology. Drug treatments; Pharmacology/Toxicology; Pharmacotherapy; Serotonin Uptake Inhibitors - adverse effects; Serotonin Uptake Inhibitors - pharmacokinetics; Serotonin Uptake Inhibitors - pharmacology; Sex Factors; Smoking; Theophylline - pharmacokinetics; Thiophenes - adverse effects; Thiophenes - pharmacokinetics; Thiophenes - pharmacology; Duloxetine; Human Liver Microsome; Fluvoxamine; Theophylline; CYP1A2 Activity; Human; Intravenous administration; Serotonin; Psychotropic; Interaction; Oral administration; Catecholamine; Reuptake inhibitor; Metabolism; In vitro; In vivo; Cytochrome P450 1A2; Neurotransmitter; Antidepressant agent; Norepinephrine; Drug interaction; Pharmacokinetics