Cinnamaldehyde and its combination with deferoxamine ameliorate inflammation, ferroptosis and hematoma expansion after intracerebral hemorrhage in mice

• Published in: Journal of neuroinflammation Vol. 22; no. 1; pp. 45 - 20
• Main Authors: Liu, Yulin, Yang, Guoqiang, Liu, Mengnan, Zhang, Yuwei, Xu, Houping, Mazhar, Maryam
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 21.02.2025; BioMed Central; BMC
• Subjects: Acrolein - administration & dosage; Acrolein - analogs & derivatives; Acrolein - therapeutic use; Aldehydes; Analysis; Animals; Antioxidants; Blood lipids; Brain; Brain damage; Brain injury; Care and treatment; Cell death; Cerebral Hemorrhage - complications; Cerebral Hemorrhage - drug therapy; Cerebral Hemorrhage - metabolism; Cerebral Hemorrhage - pathology; Deferoxamine; Deferoxamine - administration & dosage; Deferoxamine - therapeutic use; Diagnosis; Dosage and administration; Drug Therapy, Combination; Enzyme-linked immunosorbent assay; Ferroptosis; Ferroptosis - drug effects; Ferroptosis - physiology; Glutamate; Haptoglobin; Health aspects; Hematoma; Hematoma - drug therapy; Hematoma - etiology; Hematoma - pathology; Hemoglobin; Inflammation; Inflammation - drug therapy; Inflammation - etiology; Injuries; Intracerebral hemorrhage; Lipid peroxidation; Male; Membrane lipids; Mice; Mice, Inbred C57BL; Oxidative stress; Oxidative Stress - drug effects; Siderophores - administration & dosage; China; United States; Newfoundland and Labrador; Neuroprotection; Oxidative stress; Cinnamaldehyde; Cluster of differentiation; Hematoma clearance; Lipid peroxidation; Ferroptosis; Inflammation; Antioxidant; Brain injury; Intracerebral hemorrhage; Deferoxamine

Intracerebral hemorrhage (ICH) is a most serious type of hemorrhagic stroke with a continuously rising incidence globally, without effective cure available. The underlying mechanisms driving brain injury are complex and include inflammation, oxidative stress, glutamate excitotoxicity, membrane damag...