Interplay between Asters/GRAMD1s and phosphatidylserine in intermembrane transport of LDL cholesterol

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 119; no. 2
• Main Authors: Trinh, Michael N, Brown, Michael S, Seemann, Joachim, Vale, Gonçalo, McDonald, Jeffrey G, Goldstein, Joseph L, Lu, Feiran
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 11.01.2022
• Subjects: Animals; Biological Sciences; Biological Transport; Cell Membrane - metabolism; CHO Cells; Cholesterol; Cholesterol - metabolism; Cholesterol Esters - metabolism; Cholesterol, LDL - metabolism; Cricetinae; Cricetulus; Endocytosis; Endoplasmic reticulum; Endoplasmic Reticulum - metabolism; Esterification; Esters; Fatty acids; Genes; Low density lipoprotein; Lysosomes; Lysosomes - metabolism; Mammalian cells; Membrane Proteins - metabolism; Phosphatidylserine; Phosphatidylserines - metabolism; Statins; phosphatidylserine; cholesterol; mammalian cells; plasma membrane; Aster/GRAMD1 proteins

Low-density lipoprotein (LDL) delivers cholesterol to mammalian cells through receptor-mediated endocytosis. The LDL cholesterol is liberated in lysosomes and transported to the plasma membrane (PM) and from there to the endoplasmic reticulum (ER). Excess ER cholesterol is esterified with a fatty ac...