Calcium Signaling in Brain Cancers: Roles and Therapeutic Targeting

• Published in: Cancers Vol. 11; no. 2; p. 145
• Main Authors: Maklad, Ahmed, Sharma, Anjana, Azimi, Iman
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 26.01.2019; MDPI
• Subjects: Angiogenesis; Apoptosis; Binding sites; Brain cancer; Calcium channels; Calcium signalling; Calcium transport; Cancer therapies; Cell division; Cell growth; Cell proliferation; Chemotherapy; Endoplasmic reticulum; Ligands; Medulloblastoma; Meningioma; Metabolism; Metastases; Metastasis; Nervous system; Neuroblastoma; Pediatrics; Plasma; Protein transport; Proteins; Radiation therapy; Review; Roles; Spinal cord; Surgery; Therapeutic targets; Tumorigenesis; Tumors; brain cancers; calcium signaling; therapeutic targeting

Calcium signaling, in addition to its numerous physiological roles, is also implicated in several pathological conditions including cancer. An increasing body of evidence suggest critical roles of calcium signaling in the promotion of different aspects of cancer, including cell proliferation, therap...