Calcium Signaling in Brain Cancers: Roles and Therapeutic Targeting

Calcium signaling, in addition to its numerous physiological roles, is also implicated in several pathological conditions including cancer. An increasing body of evidence suggest critical roles of calcium signaling in the promotion of different aspects of cancer, including cell proliferation, therap...

Full description

Saved in:
Bibliographic Details
Published inCancers Vol. 11; no. 2; p. 145
Main Authors Maklad, Ahmed, Sharma, Anjana, Azimi, Iman
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 26.01.2019
MDPI
Subjects
Angiogenesis
Apoptosis
Binding sites
Brain cancer
Calcium channels
Calcium signalling
Calcium transport
Cancer therapies
Cell division
Cell growth
Cell proliferation
Chemotherapy
Endoplasmic reticulum
Ligands
Medulloblastoma
Meningioma
Metabolism
Metastases
Metastasis
Nervous system
Neuroblastoma
Pediatrics
Plasma
Protein transport
Proteins
Radiation therapy
Review
Roles
Spinal cord
Surgery
Therapeutic targets
Tumorigenesis
Tumors
brain cancers
calcium signaling
therapeutic targeting
Online AccessGet full text
ISSN2072-6694
2072-6694
DOI10.3390/cancers11020145

Cover

Abstract Calcium signaling, in addition to its numerous physiological roles, is also implicated in several pathological conditions including cancer. An increasing body of evidence suggest critical roles of calcium signaling in the promotion of different aspects of cancer, including cell proliferation, therapy resistance and metastatic-related processes. In many cases, this is associated with altered expression and/or activity of some calcium channels and pumps. Brain cancers have also been the subject of many of these studies. In addition to diverse roles of calcium signals in normal brain function, a number of proteins involved in calcium transport are implicated to have specific roles in some brain cancers including gliomas, medulloblastoma, neuroblastoma and meningioma. This review discusses research that has been conducted so far to understand diverse roles of Ca2+-transporting proteins in the progression of brain cancers, as well as any attempts to target these proteins towards a therapeutic approach for the control of brain cancers. Finally, some knowledge gaps in the field that may need to be further considered are also discussed.
AbstractList Calcium signaling, in addition to its numerous physiological roles, is also implicated in several pathological conditions including cancer. An increasing body of evidence suggest critical roles of calcium signaling in the promotion of different aspects of cancer, including cell proliferation, therapy resistance and metastatic-related processes. In many cases, this is associated with altered expression and/or activity of some calcium channels and pumps. Brain cancers have also been the subject of many of these studies. In addition to diverse roles of calcium signals in normal brain function, a number of proteins involved in calcium transport are implicated to have specific roles in some brain cancers including gliomas, medulloblastoma, neuroblastoma and meningioma. This review discusses research that has been conducted so far to understand diverse roles of Ca2+-transporting proteins in the progression of brain cancers, as well as any attempts to target these proteins towards a therapeutic approach for the control of brain cancers. Finally, some knowledge gaps in the field that may need to be further considered are also discussed.
Calcium signaling, in addition to its numerous physiological roles, is also implicated in several pathological conditions including cancer. An increasing body of evidence suggest critical roles of calcium signaling in the promotion of different aspects of cancer, including cell proliferation, therapy resistance and metastatic-related processes. In many cases, this is associated with altered expression and/or activity of some calcium channels and pumps. Brain cancers have also been the subject of many of these studies. In addition to diverse roles of calcium signals in normal brain function, a number of proteins involved in calcium transport are implicated to have specific roles in some brain cancers including gliomas, medulloblastoma, neuroblastoma and meningioma. This review discusses research that has been conducted so far to understand diverse roles of Ca 2+ -transporting proteins in the progression of brain cancers, as well as any attempts to target these proteins towards a therapeutic approach for the control of brain cancers. Finally, some knowledge gaps in the field that may need to be further considered are also discussed.
Calcium signaling, in addition to its numerous physiological roles, is also implicated in several pathological conditions including cancer. An increasing body of evidence suggest critical roles of calcium signaling in the promotion of different aspects of cancer, including cell proliferation, therapy resistance and metastatic-related processes. In many cases, this is associated with altered expression and/or activity of some calcium channels and pumps. Brain cancers have also been the subject of many of these studies. In addition to diverse roles of calcium signals in normal brain function, a number of proteins involved in calcium transport are implicated to have specific roles in some brain cancers including gliomas, medulloblastoma, neuroblastoma and meningioma. This review discusses research that has been conducted so far to understand diverse roles of Ca2+-transporting proteins in the progression of brain cancers, as well as any attempts to target these proteins towards a therapeutic approach for the control of brain cancers. Finally, some knowledge gaps in the field that may need to be further considered are also discussed.Calcium signaling, in addition to its numerous physiological roles, is also implicated in several pathological conditions including cancer. An increasing body of evidence suggest critical roles of calcium signaling in the promotion of different aspects of cancer, including cell proliferation, therapy resistance and metastatic-related processes. In many cases, this is associated with altered expression and/or activity of some calcium channels and pumps. Brain cancers have also been the subject of many of these studies. In addition to diverse roles of calcium signals in normal brain function, a number of proteins involved in calcium transport are implicated to have specific roles in some brain cancers including gliomas, medulloblastoma, neuroblastoma and meningioma. This review discusses research that has been conducted so far to understand diverse roles of Ca2+-transporting proteins in the progression of brain cancers, as well as any attempts to target these proteins towards a therapeutic approach for the control of brain cancers. Finally, some knowledge gaps in the field that may need to be further considered are also discussed.
Calcium signaling, in addition to its numerous physiological roles, is also implicated in several pathological conditions including cancer. An increasing body of evidence suggest critical roles of calcium signaling in the promotion of different aspects of cancer, including cell proliferation, therapy resistance and metastatic-related processes. In many cases, this is associated with altered expression and/or activity of some calcium channels and pumps. Brain cancers have also been the subject of many of these studies. In addition to diverse roles of calcium signals in normal brain function, a number of proteins involved in calcium transport are implicated to have specific roles in some brain cancers including gliomas, medulloblastoma, neuroblastoma and meningioma. This review discusses research that has been conducted so far to understand diverse roles of Ca -transporting proteins in the progression of brain cancers, as well as any attempts to target these proteins towards a therapeutic approach for the control of brain cancers. Finally, some knowledge gaps in the field that may need to be further considered are also discussed.
Author Maklad, Ahmed
Azimi, Iman
Sharma, Anjana
AuthorAffiliation Division of Pharmacy, College of Health and Medicine, University of Tasmania, Hobart, Tasmania 7001, Australia; aaettm@utas.edu.au (A.M.); asharma2@utas.edu.au (A.S.)
AuthorAffiliation_xml – name: Division of Pharmacy, College of Health and Medicine, University of Tasmania, Hobart, Tasmania 7001, Australia; aaettm@utas.edu.au (A.M.); asharma2@utas.edu.au (A.S.)
Author_xml – sequence: 1
  givenname: Ahmed
  surname: Maklad
  fullname: Maklad, Ahmed
– sequence: 2
  givenname: Anjana
  surname: Sharma
  fullname: Sharma, Anjana
– sequence: 3
  givenname: Iman
  orcidid: 0000-0001-9477-9999
  surname: Azimi
  fullname: Azimi, Iman
BackLink https://www.ncbi.nlm.nih.gov/pubmed/30691160$$D View this record in MEDLINE/PubMed
BookMark eNp1kUtLxDAUhYMoPsZZu5OCGzfVvJo0LgQtvmBA0HEd0jQdI51kTFrBf2-GcUQHzOImcL9zOLn3AGw77wwARwieESLguVZOmxARghgiWmyBfQw5zhkTdPvXew-MY3yD6RCCOOO7YI9AJhBicB9Uleq0HebZs5051Vk3y6zLroNKtVr5X2RPvjMxU67Jpq8mqIUZequzqQoz0yfFIdhpVRfN-PsegZfbm2l1n08e7x6qq0muacn7vNGINlATzExBWgaR1i1CbdkQQgyDrRCE0bYuaVFSUWOOFS4VSl-rC0S44GQELle-i6Gem0Yb1wfVyUWwcxU-pVdW_u04-ypn_kMyChnhRTI4_TYI_n0wsZdzG7XpOuWMH6LEiAtKBIFlQk820Dc_hDShRBWUU1FQihN1_DvRT5T1fBNQrAAdfIzBtFLbXvXWLwPaTiIol6uUG6tMuvMN3dr6P8UXpoqgKg
CitedBy_id crossref_primary_10_1080_01621459_2022_2034632
crossref_primary_10_1159_000512277
crossref_primary_10_3390_ijms222413635
crossref_primary_10_3389_fonc_2022_708272
crossref_primary_10_1038_s41598_019_45731_w
crossref_primary_10_3390_ijms22041831
crossref_primary_10_1016_j_apsb_2021_11_001
crossref_primary_10_1007_s00424_024_03030_y
crossref_primary_10_1016_j_omto_2022_06_004
crossref_primary_10_1021_acsptsci_4c00600
crossref_primary_10_1063_5_0004893
crossref_primary_10_1177_00368504211011836
crossref_primary_10_1016_j_psj_2023_102872
crossref_primary_10_3390_ijms22073642
crossref_primary_10_1080_15384047_2024_2338955
crossref_primary_10_3390_bioengineering12030268
crossref_primary_10_3892_etm_2021_10844
crossref_primary_10_3389_fonc_2021_578928
crossref_primary_10_3390_ijms24054883
crossref_primary_10_1097_MD_0000000000024724
crossref_primary_10_2139_ssrn_3573314
crossref_primary_10_3390_biom13101557
crossref_primary_10_1007_s12576_019_00690_9
crossref_primary_10_1016_j_lfs_2020_118291
crossref_primary_10_2147_IJN_S442446
crossref_primary_10_1016_j_ceca_2019_102109
crossref_primary_10_1038_s41416_020_0991_7
crossref_primary_10_1667_RADE_20_00101_1
crossref_primary_10_1016_j_jksus_2022_102039
crossref_primary_10_3390_ph13110368
crossref_primary_10_1016_j_semcancer_2021_05_013
crossref_primary_10_1021_acs_jnatprod_0c00038
crossref_primary_10_2174_0115680096289012240311023133
crossref_primary_10_1093_bfgp_elac025
crossref_primary_10_3389_fcell_2021_584388
crossref_primary_10_3892_etm_2023_11934
crossref_primary_10_1038_s41417_023_00616_z
crossref_primary_10_2174_1389557520666200807133659
crossref_primary_10_1088_1741_2552_ad0e7d
crossref_primary_10_3390_genes12091329
crossref_primary_10_1186_s11671_024_04172_9
crossref_primary_10_3390_cells11172657
crossref_primary_10_3389_fcell_2021_747667
crossref_primary_10_1016_j_bbr_2022_114033
crossref_primary_10_1016_j_orgel_2020_105882
crossref_primary_10_3389_fonc_2022_953098
Cites_doi 10.1007/s00018-013-1550-7
10.1158/0008-5472.CAN-09-2654
10.1007/s11940-011-0130-0
10.1111/j.1471-4159.2007.04582.x
10.1002/ijc.27588
10.1016/j.cellsig.2014.08.020
10.1530/ERC-16-0334
10.1038/nrc2818
10.1074/jbc.M114.620922
10.4103/2277-9175.148261
10.1113/JP274659
10.1016/S1470-2045(18)30347-4
10.1016/j.bbrc.2008.05.032
10.1093/carcin/bgs328
10.1038/nrm1155
10.1016/j.cell.2011.02.013
10.1038/nm.2827
10.1016/S0002-9149(97)00564-X
10.1152/ajpcell.00069.2012
10.1038/nrd.2016.230
10.1038/onc.2013.187
10.1046/j.1471-4159.2001.00169.x
10.1111/j.1476-5381.2012.01908.x
10.18632/oncotarget.8761
10.1093/carcin/bgq019
10.1038/nrc822
10.1007/s00424-013-1254-8
10.1074/jbc.R112.343061
10.1517/14728222.2013.741594
10.1016/j.canlet.2007.10.025
10.1073/pnas.032427999
10.1098/rstb.2013.0097
10.1016/j.yexmp.2011.09.005
10.1038/nrc2374
10.1242/jcs.196659
10.1038/srep18417
10.1093/neuonc/nox020
10.1152/ajpcell.00102.2011
10.5582/bst.8.1
10.1089/ars.2010.3359
10.1101/cshperspect.a004259
10.1038/nrc.2017.18
10.1007/s004150050271
10.1016/j.bbamcr.2012.11.025
10.2174/092986709787002835
10.1016/j.biocel.2013.03.005
10.1038/onc.2017.234
10.1002/glia.20994
10.4252/wjsc.v7.i9.1185
10.1002/jcp.21544
10.1200/JCO.2017.76.9992
10.1113/jphysiol.2014.274498
10.1016/S0021-5198(19)31401-5
10.1186/1750-1326-4-20
10.1111/j.1365-2184.2007.00504.x
10.1016/j.wneu.2015.09.060
10.7603/s40681-015-0019-4
10.1093/neuonc/nou283
10.1007/s00018-018-2904-y
10.1152/ajpcell.00286.2002
10.1016/j.neuron.2014.03.016
10.1038/bjc.2016.72
10.1016/j.molmed.2010.01.005
10.1002/jcp.22518
10.1097/00001756-200403220-00019
10.1186/1423-0127-16-90
10.2174/0929867321666141012172913
10.1016/j.ceca.2004.07.002
10.1186/1756-6606-5-2
10.1124/mol.114.095505
10.1016/j.biocel.2018.02.001
10.1158/0008-5472.CAN-16-2274
10.3390/ph11020048
10.1016/j.biocel.2015.09.001
10.1016/j.ijrobp.2016.06.233
10.3389/fgene.2012.00200
10.1124/mol.116.103770
10.1158/0008-5472.CAN-09-2886
10.1016/j.molonc.2015.09.006
10.1158/1078-0432.CCR-14-0833
10.1007/s00281-015-0525-1
10.1016/j.lfs.2010.09.013
10.18632/oncotarget.15283
10.1007/s11302-012-9319-2
10.1158/0008-5472.CAN-16-2347
10.1227/01.NEU.0000245597.46581.FB
10.1038/27094
10.1038/onc.2010.215
10.1093/jnci/djq217
10.1007/s11060-012-0995-0
10.3171/FOC-07/10/E10
10.1111/bph.12486
10.1158/1535-7163.MCT-16-0169-T
10.1016/j.bcp.2012.12.017
ContentType Journal Article
Copyright 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
2019 by the authors. 2019
Copyright_xml – notice: 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
– notice: 2019 by the authors. 2019
DBID AAYXX
CITATION
NPM
3V.
7T5
7TO
7XB
8FE
8FH
8FK
8G5
ABUWG
AFKRA
AZQEC
BBNVY
BENPR
BHPHI
CCPQU
DWQXO
GNUQQ
GUQSH
H94
HCIFZ
LK8
M2O
M7P
MBDVC
PHGZM
PHGZT
PIMPY
PKEHL
PQEST
PQGLB
PQQKQ
PQUKI
PRINS
Q9U
7X8
5PM
DOI 10.3390/cancers11020145
DatabaseName CrossRef
PubMed
ProQuest Central (Corporate)
Immunology Abstracts
Oncogenes and Growth Factors Abstracts
ProQuest Central (purchase pre-March 2016)
ProQuest SciTech Collection
ProQuest Natural Science Collection
ProQuest Central (Alumni) (purchase pre-March 2016)
Research Library (Alumni Edition)
ProQuest Central (Alumni)
ProQuest Central UK/Ireland
ProQuest Central Essentials
Biological Science Database
ProQuest Central
Natural Science Collection
ProQuest One
ProQuest Central Korea
ProQuest Central Student
Research Library Prep
AIDS and Cancer Research Abstracts
SciTech Premium Collection
ProQuest Biological Science Collection
Research Library
Biological Science Database
Research Library (Corporate)
ProQuest Central Premium
ProQuest One Academic
Publicly Available Content Database
ProQuest One Academic Middle East (New)
ProQuest One Academic Eastern Edition (DO NOT USE)
ProQuest One Applied & Life Sciences
ProQuest One Academic
ProQuest One Academic UKI Edition
ProQuest Central China
ProQuest Central Basic
MEDLINE - Academic
PubMed Central (Full Participant titles)
DatabaseTitle CrossRef
PubMed
Publicly Available Content Database
Research Library Prep
ProQuest Central Student
Oncogenes and Growth Factors Abstracts
ProQuest One Academic Middle East (New)
ProQuest Central Essentials
ProQuest Central (Alumni Edition)
SciTech Premium Collection
ProQuest One Community College
Research Library (Alumni Edition)
ProQuest Natural Science Collection
ProQuest Central China
ProQuest Central
ProQuest One Applied & Life Sciences
Natural Science Collection
ProQuest Central Korea
Biological Science Collection
AIDS and Cancer Research Abstracts
ProQuest Research Library
ProQuest Central (New)
ProQuest Biological Science Collection
ProQuest Central Basic
ProQuest One Academic Eastern Edition
Biological Science Database
ProQuest SciTech Collection
ProQuest One Academic UKI Edition
Immunology Abstracts
ProQuest One Academic
ProQuest One Academic (New)
ProQuest Central (Alumni)
MEDLINE - Academic
DatabaseTitleList CrossRef
Publicly Available Content Database

MEDLINE - Academic
PubMed
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: BENPR
  name: ProQuest Central
  url: https://www.proquest.com/central
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Medicine
EISSN 2072-6694
ExternalDocumentID PMC6406375
30691160
10_3390_cancers11020145
Genre Journal Article
Review
GroupedDBID ---
53G
5VS
8FE
8FH
8G5
AADQD
AAFWJ
AAYXX
ABDBF
ABUWG
ACUHS
ADBBV
AFKRA
AFZYC
ALMA_UNASSIGNED_HOLDINGS
AOIJS
AZQEC
BAWUL
BBNVY
BCNDV
BENPR
BHPHI
BPHCQ
CCPQU
CITATION
DIK
DWQXO
E3Z
EBD
ESX
GNUQQ
GUQSH
GX1
HCIFZ
HYE
IAO
IHR
KQ8
LK8
M2O
M48
M7P
MODMG
M~E
OK1
P6G
PGMZT
PHGZM
PHGZT
PIMPY
PQQKQ
PROAC
RPM
TUS
3V.
GROUPED_DOAJ
NPM
7T5
7TO
7XB
8FK
H94
MBDVC
PKEHL
PQEST
PQGLB
PQUKI
PRINS
Q9U
7X8
5PM
ID FETCH-LOGICAL-c487t-dc14d0c326e53f601ccf11f8d333e60f99364fb845849b272a28a1201b5137973
IEDL.DBID M48
ISSN 2072-6694
IngestDate Thu Aug 21 13:40:35 EDT 2025
Fri Jul 11 01:12:04 EDT 2025
Fri Jul 25 12:01:40 EDT 2025
Thu Jan 02 23:02:52 EST 2025
Thu Apr 24 23:02:32 EDT 2025
Tue Jul 01 01:51:34 EDT 2025
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 2
Keywords brain cancers
calcium signaling
therapeutic targeting
Language English
License https://creativecommons.org/licenses/by/4.0
Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c487t-dc14d0c326e53f601ccf11f8d333e60f99364fb845849b272a28a1201b5137973
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
ObjectType-Review-3
content type line 23
These authors contributed equally to this work.
ORCID 0000-0001-9477-9999
OpenAccessLink http://journals.scholarsportal.info/openUrl.xqy?doi=10.3390/cancers11020145
PMID 30691160
PQID 2547495442
PQPubID 2032421
ParticipantIDs pubmedcentral_primary_oai_pubmedcentral_nih_gov_6406375
proquest_miscellaneous_2179439308
proquest_journals_2547495442
pubmed_primary_30691160
crossref_citationtrail_10_3390_cancers11020145
crossref_primary_10_3390_cancers11020145
ProviderPackageCode CITATION
AAYXX
PublicationCentury 2000
PublicationDate 20190126
PublicationDateYYYYMMDD 2019-01-26
PublicationDate_xml – month: 1
  year: 2019
  text: 20190126
  day: 26
PublicationDecade 2010
PublicationPlace Switzerland
PublicationPlace_xml – name: Switzerland
– name: Basel
PublicationTitle Cancers
PublicationTitleAlternate Cancers (Basel)
PublicationYear 2019
Publisher MDPI AG
MDPI
Publisher_xml – name: MDPI AG
– name: MDPI
References ref_91
Azimi (ref_17) 2016; 23
Chigurupati (ref_58) 2010; 70
Fiest (ref_23) 2015; 17
Wondergem (ref_61) 2008; 372
Chen (ref_50) 2014; 8
Burgoyne (ref_35) 2012; 5
Karsy (ref_92) 2016; 86
Napolitano (ref_29) 1998; 245
Kheirollahi (ref_22) 2015; 4
Fang (ref_72) 2013; 45
Kang (ref_94) 2017; 16
Wei (ref_71) 2008; 260
Liu (ref_42) 2011; 91
Thiery (ref_18) 2002; 2
Mahalingam (ref_87) 2016; 114
Azimi (ref_11) 2014; 171
Karajannis (ref_25) 2008; 217
Wondergem (ref_62) 2009; 16
(ref_81) 2015; 5
Omuro (ref_90) 2018; 36
Rosenberg (ref_33) 2011; 3
Marambaud (ref_36) 2009; 4
Nabissi (ref_66) 2010; 31
Li (ref_44) 2014; 86
Adinolfi (ref_70) 2015; 22
Westcarth (ref_28) 2012; 3
Carafoli (ref_10) 2002; 99
Dragu (ref_31) 2015; 7
Davis (ref_19) 2014; 33
Peters (ref_96) 2017; 36
Bomben (ref_53) 2011; 226
Morrone (ref_32) 2016; 90
Brini (ref_38) 2014; 71
Theeler (ref_27) 2011; 13
Zundorf (ref_34) 2011; 14
Wei (ref_76) 2017; 595
Cuddapah (ref_16) 2011; 301
Shapovalov (ref_8) 2016; 38
Grimaldi (ref_39) 2016; 7
Parkash (ref_21) 2010; 87
Santos (ref_97) 2017; 16
Zhang (ref_49) 2017; 77
Panner (ref_77) 2005; 37
Stock (ref_64) 2012; 18
Seifert (ref_95) 2014; 592
Bomben (ref_51) 2008; 41
Morelli (ref_67) 2012; 131
Bell (ref_82) 2013; 1833
Ragel (ref_86) 2007; 23
Usachev (ref_83) 2001; 76
Niklasson (ref_93) 2017; 77
Hanahan (ref_14) 2011; 144
Azimi (ref_56) 2017; 130
Gehring (ref_73) 2012; 8
Ragel (ref_85) 2006; 59
Prevarskaya (ref_15) 2010; 16
Azimi (ref_9) 2016; 10
Arcangeli (ref_13) 2009; 16
Singh (ref_20) 2010; 29
Roderick (ref_5) 2008; 8
Nabissi (ref_65) 2013; 34
Santoni (ref_45) 2012; 166
Azimi (ref_55) 2018; 97
Monteith (ref_3) 2017; 17
Huse (ref_24) 2010; 10
Gajjar (ref_26) 2014; 20
Azimi (ref_40) 2018; 75
Simms (ref_43) 2014; 82
Keir (ref_48) 2013; 111
Berridge (ref_12) 1998; 395
Monteith (ref_4) 2012; 287
Chen (ref_79) 2013; 304
Holdhoff (ref_88) 2017; 19
Yoshida (ref_68) 1997; 74
Kang (ref_69) 2010; 70
Ding (ref_54) 2010; 102
Valerie (ref_47) 2013; 85
Motiani (ref_41) 2013; 465
Chen (ref_80) 2014; 289
Nikoletopoulou (ref_37) 2012; 3
Padma (ref_30) 2015; 5
Bomben (ref_52) 2010; 58
Amantini (ref_63) 2007; 102
Prevarskaya (ref_6) 2013; 17
Ishii (ref_59) 2007; 27
Gehring (ref_74) 2015; 68
Li (ref_57) 2015; 128
Berridge (ref_2) 2003; 4
ref_1
Abernethy (ref_46) 1997; 80
Chemin (ref_78) 2004; 15
Florea (ref_84) 2017; 8
Gendron (ref_75) 2003; 284
ref_7
Liu (ref_60) 2014; 26
Kluytenaar (ref_89) 2016; 96
References_xml – volume: 71
  start-page: 2787
  year: 2014
  ident: ref_38
  article-title: Neuronal calcium signaling: Function and dysfunction
  publication-title: Cell. Mol. Life Sci.
  doi: 10.1007/s00018-013-1550-7
– volume: 70
  start-page: 418
  year: 2010
  ident: ref_58
  article-title: Receptor channel TRPC6 is a key mediator of Notch-driven glioblastoma growth and invasiveness
  publication-title: Cancer Res.
  doi: 10.1158/0008-5472.CAN-09-2654
– volume: 13
  start-page: 386
  year: 2011
  ident: ref_27
  article-title: High-grade gliomas
  publication-title: Curr. Treat. Options Neurol.
  doi: 10.1007/s11940-011-0130-0
– volume: 102
  start-page: 977
  year: 2007
  ident: ref_63
  article-title: Capsaicin-induced apoptosis of glioma cells is mediated by TRPV1 vanilloid receptor and requires p38 MAPK activation
  publication-title: J. Neurochem.
  doi: 10.1111/j.1471-4159.2007.04582.x
– volume: 131
  start-page: E1067
  year: 2012
  ident: ref_67
  article-title: The transient receptor potential vanilloid-2 cation channel impairs glioblastoma stem-like cell proliferation and promotes differentiation
  publication-title: Int. J. Cancer
  doi: 10.1002/ijc.27588
– volume: 26
  start-page: 2773
  year: 2014
  ident: ref_60
  article-title: TRPM7 channels regulate glioma stem cell through STAT3 and Notch signaling pathways
  publication-title: Cell. Signal.
  doi: 10.1016/j.cellsig.2014.08.020
– volume: 23
  start-page: R517
  year: 2016
  ident: ref_17
  article-title: Plasma membrane ion channels and epithelial to mesenchymal transition in cancer cells
  publication-title: Endocr. Relat. Cancer
  doi: 10.1530/ERC-16-0334
– volume: 10
  start-page: 319
  year: 2010
  ident: ref_24
  article-title: Targeting brain cancer: Advances in the molecular pathology of malignant glioma and medulloblastoma
  publication-title: Nat. Rev. Cancer
  doi: 10.1038/nrc2818
– volume: 289
  start-page: 36284
  year: 2014
  ident: ref_80
  article-title: A splice variant of the human ion channel TRPM2 modulates neuroblastoma tumor growth through hypoxia-inducible factor (HIF)-1/2alpha
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M114.620922
– volume: 4
  start-page: 4
  year: 2015
  ident: ref_22
  article-title: Brain tumors: Special characters for research and banking
  publication-title: Adv. Biomed. Res.
  doi: 10.4103/2277-9175.148261
– volume: 595
  start-page: 5525
  year: 2017
  ident: ref_76
  article-title: Functional expression of calcium-permeable canonical transient receptor potential 4-containing channels promotes migration of medulloblastoma cells
  publication-title: J. Physiol.
  doi: 10.1113/JP274659
– ident: ref_91
  doi: 10.1016/S1470-2045(18)30347-4
– volume: 372
  start-page: 210
  year: 2008
  ident: ref_61
  article-title: HGF/SF and menthol increase human glioblastoma cell calcium and migration
  publication-title: Biochem. Biophys. Res. Commun.
  doi: 10.1016/j.bbrc.2008.05.032
– volume: 34
  start-page: 48
  year: 2013
  ident: ref_65
  article-title: Triggering of the TRPV2 channel by cannabidiol sensitizes glioblastoma cells to cytotoxic chemotherapeutic agents
  publication-title: Carcinogenesis
  doi: 10.1093/carcin/bgs328
– volume: 4
  start-page: 517
  year: 2003
  ident: ref_2
  article-title: Calcium signalling: Dynamics, homeostasis and remodelling
  publication-title: Nat. Rev. Mol. Cell Biol.
  doi: 10.1038/nrm1155
– volume: 144
  start-page: 646
  year: 2011
  ident: ref_14
  article-title: Hallmarks of Cancer: The Next Generation
  publication-title: Cell
  doi: 10.1016/j.cell.2011.02.013
– volume: 18
  start-page: 1232
  year: 2012
  ident: ref_64
  article-title: Neural precursor cells induce cell death of high-grade astrocytomas through stimulation of TRPV1
  publication-title: Nat. Med.
  doi: 10.1038/nm.2827
– volume: 80
  start-page: 4C
  year: 1997
  ident: ref_46
  article-title: Pharmacologic and pharmacokinetic profile of mibefradil, a T- and L-type calcium channel antagonist
  publication-title: Am. J. Cardiol.
  doi: 10.1016/S0002-9149(97)00564-X
– volume: 304
  start-page: C548
  year: 2013
  ident: ref_79
  article-title: Role of TRPM2 in cell proliferation and susceptibility to oxidative stress
  publication-title: Am. J. Physiol. Cell Physiol.
  doi: 10.1152/ajpcell.00069.2012
– volume: 16
  start-page: 19
  year: 2017
  ident: ref_97
  article-title: A comprehensive map of molecular drug targets
  publication-title: Nat. Rev. Drug Discov.
  doi: 10.1038/nrd.2016.230
– volume: 33
  start-page: 2307
  year: 2014
  ident: ref_19
  article-title: Induction of epithelial-mesenchymal transition (EMT) in breast cancer cells is calcium signal dependent
  publication-title: Oncogene
  doi: 10.1038/onc.2013.187
– volume: 76
  start-page: 1756
  year: 2001
  ident: ref_83
  article-title: Differentiation induces up-regulation of plasma membrane Ca(2+)-ATPase and concomitant increase in Ca(2+) efflux in human neuroblastoma cell line IMR-32
  publication-title: J. Neurochem.
  doi: 10.1046/j.1471-4159.2001.00169.x
– volume: 166
  start-page: 1244
  year: 2012
  ident: ref_45
  article-title: Functional role of T-type calcium channels in tumour growth and progression: Prospective in cancer therapy
  publication-title: Br. J. Pharmacol.
  doi: 10.1111/j.1476-5381.2012.01908.x
– volume: 7
  start-page: 30781
  year: 2016
  ident: ref_39
  article-title: KCa3.1 channel inhibition sensitizes malignant gliomas to temozolomide treatment
  publication-title: Oncotarget
  doi: 10.18632/oncotarget.8761
– volume: 31
  start-page: 794
  year: 2010
  ident: ref_66
  article-title: TRPV2 channel negatively controls glioma cell proliferation and resistance to Fas-induced apoptosis in ERK-dependent manner
  publication-title: Carcinogenesis
  doi: 10.1093/carcin/bgq019
– volume: 2
  start-page: 442
  year: 2002
  ident: ref_18
  article-title: Epithelial-mesenchymal transitions in tumour progression
  publication-title: Nat. Rev. Cancer
  doi: 10.1038/nrc822
– volume: 465
  start-page: 1249
  year: 2013
  ident: ref_41
  article-title: STIM1 and Orai1 mediate CRAC channel activity and are essential for human glioblastoma invasion
  publication-title: Pflugers Arch.
  doi: 10.1007/s00424-013-1254-8
– volume: 287
  start-page: 31666
  year: 2012
  ident: ref_4
  article-title: Calcium channels and pumps in cancer: Changes and consequences
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.R112.343061
– volume: 17
  start-page: 225
  year: 2013
  ident: ref_6
  article-title: Targeting Ca(2)(+) transport in cancer: Close reality or long perspective?
  publication-title: Expert Opin. Ther. Targets
  doi: 10.1517/14728222.2013.741594
– volume: 260
  start-page: 79
  year: 2008
  ident: ref_71
  article-title: Expression and function of the P2X(7) receptor in rat C6 glioma cells
  publication-title: Cancer Lett.
  doi: 10.1016/j.canlet.2007.10.025
– volume: 99
  start-page: 1115
  year: 2002
  ident: ref_10
  article-title: Calcium signaling: A tale for all seasons
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.032427999
– ident: ref_1
  doi: 10.1098/rstb.2013.0097
– volume: 91
  start-page: 753
  year: 2011
  ident: ref_42
  article-title: Calcium entry via ORAI1 regulates glioblastoma cell proliferation and apoptosis
  publication-title: Exp. Mol. Pathol.
  doi: 10.1016/j.yexmp.2011.09.005
– volume: 8
  start-page: 361
  year: 2008
  ident: ref_5
  article-title: Ca2+ signalling checkpoints in cancer: Remodelling Ca2+ for cancer cell proliferation and survival
  publication-title: Nat. Rev. Cancer
  doi: 10.1038/nrc2374
– volume: 130
  start-page: 2292
  year: 2017
  ident: ref_56
  article-title: TRPC1 is a differential regulator of hypoxia-mediated events and Akt signalling in PTEN-deficient breast cancer cells
  publication-title: J. Cell Sci.
  doi: 10.1242/jcs.196659
– volume: 5
  start-page: 18417
  year: 2015
  ident: ref_81
  article-title: PI3K/Akt signaling pathway triggers P2X7 receptor expression as a pro-survival factor of neuroblastoma cells under limiting growth conditions
  publication-title: Sci. Rep.
  doi: 10.1038/srep18417
– volume: 19
  start-page: 845
  year: 2017
  ident: ref_88
  article-title: Timed sequential therapy of the selective T-type calcium channel blocker mibefradil and temozolomide in patients with recurrent high-grade gliomas
  publication-title: Neuro. Oncol.
  doi: 10.1093/neuonc/nox020
– volume: 301
  start-page: C541
  year: 2011
  ident: ref_16
  article-title: Ion channels and transporters in cancer. 2. Ion channels and the control of cancer cell migration
  publication-title: Am. J. Physiol. Cell Physiol.
  doi: 10.1152/ajpcell.00102.2011
– volume: 8
  start-page: 1
  year: 2014
  ident: ref_50
  article-title: Transient receptor potential (TRP) channels, promising potential diagnostic and therapeutic tools for cancer
  publication-title: Biosci. Trends
  doi: 10.5582/bst.8.1
– volume: 14
  start-page: 1275
  year: 2011
  ident: ref_34
  article-title: Calcium dysregulation and homeostasis of neural calcium in the molecular mechanisms of neurodegenerative diseases provide multiple targets for neuroprotection
  publication-title: Antioxid. Redox Signal.
  doi: 10.1089/ars.2010.3359
– volume: 3
  start-page: a004259
  year: 2011
  ident: ref_33
  article-title: Calcium signaling in neuronal development
  publication-title: Cold Spring Harb. Perspect. Biol.
  doi: 10.1101/cshperspect.a004259
– volume: 17
  start-page: 367
  year: 2017
  ident: ref_3
  article-title: The calcium-cancer signalling nexus
  publication-title: Nat. Rev. Cancer
  doi: 10.1038/nrc.2017.18
– volume: 245
  start-page: 695
  year: 1998
  ident: ref_29
  article-title: Neurological complications of radiotherapy and chemotherapy
  publication-title: J. Neurol.
  doi: 10.1007/s004150050271
– volume: 1833
  start-page: 643
  year: 2013
  ident: ref_82
  article-title: Store-operated Ca(2+) entry in proliferating and retinoic acid-differentiated N- and S-type neuroblastoma cells
  publication-title: Biochim. Biophys. Acta
  doi: 10.1016/j.bbamcr.2012.11.025
– volume: 16
  start-page: 66
  year: 2009
  ident: ref_13
  article-title: Targeting ion channels in cancer: A novel frontier in antineoplastic therapy
  publication-title: Curr. Med. Chem.
  doi: 10.2174/092986709787002835
– volume: 45
  start-page: 1109
  year: 2013
  ident: ref_72
  article-title: P2X7R suppression promotes glioma growth through epidermal growth factor receptor signal pathway
  publication-title: Int. J. Biochem. Cell Biol.
  doi: 10.1016/j.biocel.2013.03.005
– volume: 36
  start-page: 6490
  year: 2017
  ident: ref_96
  article-title: Oncosis and apoptosis induction by activation of an overexpressed ion channel in breast cancer cells
  publication-title: Oncogene
  doi: 10.1038/onc.2017.234
– volume: 58
  start-page: 1145
  year: 2010
  ident: ref_52
  article-title: Disruption of transient receptor potential canonical channel 1 causes incomplete cytokinesis and slows the growth of human malignant gliomas
  publication-title: Glia
  doi: 10.1002/glia.20994
– volume: 7
  start-page: 1185
  year: 2015
  ident: ref_31
  article-title: Therapies targeting cancer stem cells: Current trends and future challenges
  publication-title: World J. Stem Cells
  doi: 10.4252/wjsc.v7.i9.1185
– volume: 217
  start-page: 584
  year: 2008
  ident: ref_25
  article-title: Treatment of pediatric brain tumors
  publication-title: J. Cell. Physiol.
  doi: 10.1002/jcp.21544
– volume: 36
  start-page: 1702
  year: 2018
  ident: ref_90
  article-title: Multicenter Phase IB Trial of Carboxyamidotriazole Orotate and Temozolomide for Recurrent and Newly Diagnosed Glioblastoma and Other Anaplastic Gliomas
  publication-title: J. Clin. Oncol.
  doi: 10.1200/JCO.2017.76.9992
– volume: 592
  start-page: 5109
  year: 2014
  ident: ref_95
  article-title: Bradykinin enhances invasion of malignant glioma into the brain parenchyma by inducing cells to undergo amoeboid migration
  publication-title: J. Physiol.
  doi: 10.1113/jphysiol.2014.274498
– volume: 3
  start-page: 11
  year: 2012
  ident: ref_28
  article-title: Neurotoxicity associated with cancer therapy
  publication-title: J. Adv. Pract. Oncol.
– volume: 74
  start-page: 125
  year: 1997
  ident: ref_68
  article-title: Structure and function of inositol 1,4,5-trisphosphate receptor
  publication-title: Jpn. J. Pharmacol.
  doi: 10.1016/S0021-5198(19)31401-5
– volume: 4
  start-page: 20
  year: 2009
  ident: ref_36
  article-title: Calcium signaling in neurodegeneration
  publication-title: Mol. Neurodegener.
  doi: 10.1186/1750-1326-4-20
– volume: 41
  start-page: 98
  year: 2008
  ident: ref_51
  article-title: Inhibition of transient receptor potential canonical channels impairs cytokinesis in human malignant gliomas
  publication-title: Cell Prolif.
  doi: 10.1111/j.1365-2184.2007.00504.x
– volume: 86
  start-page: 210
  year: 2016
  ident: ref_92
  article-title: Combined Hydroxyurea and Verapamil in the Clinical Treatment of Refractory Meningioma: Human and Orthotopic Xenograft Studies
  publication-title: World Neurosurg.
  doi: 10.1016/j.wneu.2015.09.060
– volume: 5
  start-page: 19
  year: 2015
  ident: ref_30
  article-title: An overview of targeted cancer therapy
  publication-title: Biomedicine
  doi: 10.7603/s40681-015-0019-4
– volume: 17
  start-page: 776
  year: 2015
  ident: ref_23
  article-title: The worldwide incidence and prevalence of primary brain tumors: A systematic review and meta-analysis
  publication-title: Neuro Oncol.
  doi: 10.1093/neuonc/nou283
– volume: 75
  start-page: 4525
  year: 2018
  ident: ref_40
  article-title: Pharmacological inhibition of store-operated calcium entry in MDA-MB-468 basal A breast cancer cells: Consequences on calcium signalling, cell migration and proliferation
  publication-title: Cell. Mol. Life Sci.
  doi: 10.1007/s00018-018-2904-y
– volume: 284
  start-page: C571
  year: 2003
  ident: ref_75
  article-title: Mechanisms of P2X7 receptor-mediated ERK1/2 phosphorylation in human astrocytoma cells
  publication-title: Am. J. Physiol. Cell Physiol.
  doi: 10.1152/ajpcell.00286.2002
– volume: 82
  start-page: 24
  year: 2014
  ident: ref_43
  article-title: Neuronal voltage-gated calcium channels: Structure, function, and dysfunction
  publication-title: Neuron
  doi: 10.1016/j.neuron.2014.03.016
– volume: 114
  start-page: 986
  year: 2016
  ident: ref_87
  article-title: Mipsagargin, a novel thapsigargin-based PSMA-activated prodrug: Results of a first-in-man phase I clinical trial in patients with refractory, advanced or metastatic solid tumours
  publication-title: Br. J. Cancer
  doi: 10.1038/bjc.2016.72
– volume: 16
  start-page: 107
  year: 2010
  ident: ref_15
  article-title: Ion channels and the hallmarks of cancer
  publication-title: Trends Mol. Med.
  doi: 10.1016/j.molmed.2010.01.005
– volume: 226
  start-page: 1879
  year: 2011
  ident: ref_53
  article-title: Transient receptor potential canonical channels are essential for chemotactic migration of human malignant gliomas
  publication-title: J. Cell. Physiol.
  doi: 10.1002/jcp.22518
– volume: 128
  start-page: 3317
  year: 2015
  ident: ref_57
  article-title: Crucial role of TRPC6 in maintaining the stability of HIF-1alpha in glioma cells under hypoxia
  publication-title: J. Cell Sci.
– volume: 15
  start-page: 671
  year: 2004
  ident: ref_78
  article-title: Ca(v)3.2 calcium channels control an autocrine mechanism that promotes neuroblastoma cell differentiation
  publication-title: Neuroreport
  doi: 10.1097/00001756-200403220-00019
– volume: 16
  start-page: 90
  year: 2009
  ident: ref_62
  article-title: Menthol increases human glioblastoma intracellular Ca2+, BK channel activity and cell migration
  publication-title: J. Biomed. Sci.
  doi: 10.1186/1423-0127-16-90
– volume: 22
  start-page: 878
  year: 2015
  ident: ref_70
  article-title: Emerging roles of P2X receptors in cancer
  publication-title: Curr. Med. Chem.
  doi: 10.2174/0929867321666141012172913
– volume: 37
  start-page: 105
  year: 2005
  ident: ref_77
  article-title: Variation of T-type calcium channel protein expression affects cell division of cultured tumor cells
  publication-title: Cell Calcium
  doi: 10.1016/j.ceca.2004.07.002
– volume: 5
  start-page: 2
  year: 2012
  ident: ref_35
  article-title: Understanding the physiological roles of the neuronal calcium sensor proteins
  publication-title: Mol. Brain
  doi: 10.1186/1756-6606-5-2
– volume: 86
  start-page: 760
  year: 2014
  ident: ref_44
  article-title: Potentiation of high voltage-activated calcium channels by 4-aminopyridine depends on subunit composition
  publication-title: Mol. Pharmacol.
  doi: 10.1124/mol.114.095505
– volume: 97
  start-page: 73
  year: 2018
  ident: ref_55
  article-title: The interplay between HIF-1 and calcium signalling in cancer
  publication-title: Int. J. Biochem. Cell Biol.
  doi: 10.1016/j.biocel.2018.02.001
– volume: 77
  start-page: 1741
  year: 2017
  ident: ref_93
  article-title: Membrane-Depolarizing Channel Blockers Induce Selective Glioma Cell Death by Impairing Nutrient Transport and Unfolded Protein/Amino Acid Responses
  publication-title: Cancer Res.
  doi: 10.1158/0008-5472.CAN-16-2274
– ident: ref_7
  doi: 10.3390/ph11020048
– volume: 68
  start-page: 92
  year: 2015
  ident: ref_74
  article-title: P2X7 receptor as predictor gene for glioma radiosensitivity and median survival
  publication-title: Int. J. Biochem. Cell Biol.
  doi: 10.1016/j.biocel.2015.09.001
– volume: 96
  start-page: S93
  year: 2016
  ident: ref_89
  article-title: Mibefradil dihydrochloride with hypofractionated radiation for recurrent glioblastoma: Preliminary results of a phase I dose expansion trial
  publication-title: Int. J. Radiat. Oncol. Bio. Phys.
  doi: 10.1016/j.ijrobp.2016.06.233
– volume: 3
  start-page: 200
  year: 2012
  ident: ref_37
  article-title: Calcium homeostasis in aging neurons
  publication-title: Front Genet
  doi: 10.3389/fgene.2012.00200
– volume: 90
  start-page: 403
  year: 2016
  ident: ref_32
  article-title: Calcium Channels and Associated Receptors in Malignant Brain Tumor Therapy
  publication-title: Mol. Pharmacol.
  doi: 10.1124/mol.116.103770
– volume: 70
  start-page: 1173
  year: 2010
  ident: ref_69
  article-title: Caffeine-mediated inhibition of calcium release channel inositol 1,4,5-trisphosphate receptor subtype 3 blocks glioblastoma invasion and extends survival
  publication-title: Cancer Res.
  doi: 10.1158/0008-5472.CAN-09-2886
– volume: 10
  start-page: 166
  year: 2016
  ident: ref_9
  article-title: Altered purinergic receptor-Ca2+ signaling associated with hypoxia-induced epithelial-mesenchymal transition in breast cancer cells
  publication-title: Mol. Oncol.
  doi: 10.1016/j.molonc.2015.09.006
– volume: 20
  start-page: 5630
  year: 2014
  ident: ref_26
  article-title: Molecular insights into pediatric brain tumors have the potential to transform therapy
  publication-title: Clin. Cancer Res.
  doi: 10.1158/1078-0432.CCR-14-0833
– volume: 38
  start-page: 357
  year: 2016
  ident: ref_8
  article-title: Role of TRP ion channels in cancer and tumorigenesis
  publication-title: Semin. Immunopathol.
  doi: 10.1007/s00281-015-0525-1
– volume: 87
  start-page: 587
  year: 2010
  ident: ref_21
  article-title: Calcium wave signaling in cancer cells
  publication-title: Life Sci.
  doi: 10.1016/j.lfs.2010.09.013
– volume: 8
  start-page: 22876
  year: 2017
  ident: ref_84
  article-title: Calcium-regulatory proteins as modulators of chemotherapy in human neuroblastoma
  publication-title: Oncotarget
  doi: 10.18632/oncotarget.15283
– volume: 8
  start-page: 729
  year: 2012
  ident: ref_73
  article-title: P2X7 receptor activation leads to increased cell death in a radiosensitive human glioma cell line
  publication-title: Purinergic Signal.
  doi: 10.1007/s11302-012-9319-2
– volume: 77
  start-page: 3479
  year: 2017
  ident: ref_49
  article-title: Targetable T-type Calcium Channels Drive Glioblastoma
  publication-title: Cancer Res.
  doi: 10.1158/0008-5472.CAN-16-2347
– volume: 27
  start-page: 3987
  year: 2007
  ident: ref_59
  article-title: Facilitation of H2O2-induced A172 human glioblastoma cell death by insertion of oxidative stress-sensitive TRPM2 channels
  publication-title: Anticancer Res.
– volume: 59
  start-page: 1109
  year: 2006
  ident: ref_85
  article-title: Calcium channel antagonists augment hydroxyurea- and ru486-induced inhibition of meningioma growth in vivo and in vitro
  publication-title: Neurosurgery
  doi: 10.1227/01.NEU.0000245597.46581.FB
– volume: 395
  start-page: 645
  year: 1998
  ident: ref_12
  article-title: Calcium—A life and death signal
  publication-title: Nature
  doi: 10.1038/27094
– volume: 29
  start-page: 4741
  year: 2010
  ident: ref_20
  article-title: EMT, cancer stem cells and drug resistance: An emerging axis of evil in the war on cancer
  publication-title: Oncogene
  doi: 10.1038/onc.2010.215
– volume: 102
  start-page: 1052
  year: 2010
  ident: ref_54
  article-title: Essential role of TRPC6 channels in G2/M phase transition and development of human glioma
  publication-title: J. Natl. Cancer Inst.
  doi: 10.1093/jnci/djq217
– volume: 111
  start-page: 97
  year: 2013
  ident: ref_48
  article-title: Mibefradil, a novel therapy for glioblastoma multiforme: Cell cycle synchronization and interlaced therapy in a murine model
  publication-title: J. Neurooncol.
  doi: 10.1007/s11060-012-0995-0
– volume: 23
  start-page: E10
  year: 2007
  ident: ref_86
  article-title: Chronic suppressive therapy with calcium channel antagonists for refractory meningiomas
  publication-title: Neurosurg. Focus
  doi: 10.3171/FOC-07/10/E10
– volume: 171
  start-page: 945
  year: 2014
  ident: ref_11
  article-title: Calcium influx pathways in breast cancer: Opportunities for pharmacological intervention
  publication-title: Br. J. Pharmacol.
  doi: 10.1111/bph.12486
– volume: 16
  start-page: 217
  year: 2017
  ident: ref_94
  article-title: Trifluoperazine, a Well-Known Antipsychotic, Inhibits Glioblastoma Invasion by Binding to Calmodulin and Disinhibiting Calcium Release Channel IP3R
  publication-title: Mol. Cancer Ther.
  doi: 10.1158/1535-7163.MCT-16-0169-T
– volume: 85
  start-page: 888
  year: 2013
  ident: ref_47
  article-title: Inhibition of T-type calcium channels disrupts Akt signaling and promotes apoptosis in glioblastoma cells
  publication-title: Biochem. Pharmacol.
  doi: 10.1016/j.bcp.2012.12.017
SSID ssj0000331767
Score 2.386672
SecondaryResourceType review_article
Snippet Calcium signaling, in addition to its numerous physiological roles, is also implicated in several pathological conditions including cancer. An increasing body...
SourceID pubmedcentral
proquest
pubmed
crossref
SourceType Open Access Repository
Aggregation Database
Index Database
Enrichment Source
StartPage 145
SubjectTerms Angiogenesis
Apoptosis
Binding sites
Brain cancer
Calcium channels
Calcium signalling
Calcium transport
Cancer therapies
Cell division
Cell growth
Cell proliferation
Chemotherapy
Endoplasmic reticulum
Ligands
Medulloblastoma
Meningioma
Metabolism
Metastases
Metastasis
Nervous system
Neuroblastoma
Pediatrics
Plasma
Protein transport
Proteins
Radiation therapy
Review
Roles
Spinal cord
Surgery
Therapeutic targets
Tumorigenesis
Tumors
SummonAdditionalLinks – databaseName: ProQuest Central
  dbid: BENPR
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3dS8MwED_8APFF_LZ-EcEHX6Jtk6apL6LDMYQN0Qm-lTZNdKCduu3_99Jm1Sna1yY0vUvvfpe7_g7gWISKxzkzVBqpKTcypwnnOc01S7gJg0JWRNrdnug88JvH6NEduI1cWeXUJlaGuhgqe0Z-hoFMjGCe8_Di7Z3arlE2u-paaMzDIppgicHX4tV17_auOWXxGfpHEdecPgzj-zNlhfkxQq8X2ozarDv6hTF_lkp-8z3tVVhxoJFc1lpegzldrsNS16XFN6DVyl7UYPJK7gdPFliXT2RQkivb_YG06pWckztL3USysiD9r3-uSL-qBMcZm_DQvu63OtR1R6AKg4wxLVTAC18h_NIRMxhXKWWCwMiCMaaFbxB4CG5yaROhSR7GYRbKLMCXzqOAxUnMtmChHJZ6B0im_ALduNA-R8MpEtQrFyaJ8AqSIjMenE6FlCpHHW47WLykGEJYqaY_pOrBSTPhrWbN-Hvo_lTqqft8RumXsj04am7jxrfZjKzUwwmOqbjtEuZLD7ZrJTXPwjgIjbjwPYhn1NcMsKTas3fKwXNFri0Q4bA42v1_WXuwjKu3lWY0FPuwMP6Y6ANEJ-P80G3BT7895V4
  priority: 102
  providerName: ProQuest
Title Calcium Signaling in Brain Cancers: Roles and Therapeutic Targeting
URI https://www.ncbi.nlm.nih.gov/pubmed/30691160
https://www.proquest.com/docview/2547495442
https://www.proquest.com/docview/2179439308
https://pubmed.ncbi.nlm.nih.gov/PMC6406375
Volume 11
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3dS8MwED_8APFF_LY6RwQffKm2TZq0goiOqQgT0Q32Vto00cKsOjfQ_95L22069cW-Jkebu1zud1z6O4B97kkmEqrtQAfKZjpI7JCxxE4UDZn23DQoiLRbN_yqw667fnfSDqhS4NuvqZ3pJ9Xp9w7fXz9O0eFPTMaJKfuRNPrpv2Eg80yRbBbmMSwJ46WtCusXxzLFUMlFSe_zm9wiLCB-Rucv6Cq_BKkfyHP6AuWXiHSxDEsVlCRnpe1XYEblq7DQqorla9BoxD2ZDZ_IffZg4Hb-QLKcnJueEKRRftQxuTOETiTOU9Ke_IlF2sX9cJRYh85Fs924squeCbbE1GNgp9JlqSMRlCmfasy2pNSuq4OUUqq4oxGOcKaTwJRHw8QTXuwFsYvrT3yXilDQDZjLn3O1BSSWTorBnSuH4XHKQ7Q24zr08XHDNNYWHI6UFMmKUNz0tehFmFgYBUdTCrbgYCzwUnJp_D21NtJ6NNoTEeayAvM5xjwL9sbD6A6mxhHn6nmIcwrGu5A6gQWbpZHG7xpZ1wLxzXzjCYZq-_tInj0WlNsccQ8V_va_JXdgERdmrqbZHq_B3KA_VLsIZwZJHebPmze3d3WYvey69WLTfgKmkPeT
linkProvider Scholars Portal
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV3dT9swED-xIm17mQb7ysaYkTZpLx6J7TgxEpqggMqg1cSKxFtIHJtVYimjrSb-qf2NnPPFygRv5NV24tydfb_zne8APkqmRZRxS2MbGypsnFElREYzw5WwLMjjMpF2fyB7x-LbSXiyAH-buzAurLLZE8uNOh9rd0a-joZMhGBeCPb14jd1VaOcd7UpoVGJxYG5-oMm22Rzfwf5-4mxvd1ht0frqgJUIzif0lwHIvc1whYTcov2iNY2CGycc86N9C0qbClsFjsHospYxFIWpwHqySwMeKQiju99BIuC49AOLG7vDr4ftac6Pkd9LKMqhxDnyl_XjnmXE9SyzHnw5tXff5j2dmjmP7pu7zk8q0Eq2aqkagkWTLEMj_u1G_4FdLvpuR7NfpEfozMH5IszMirItqs2QbrVTDbIkUsVRdIiJ8ObO15kWEae44iXcPwgdHsFnWJcmDdAUu3nCBuk8QVu1FKhHAlpVYhPoPLUevClIVKi61TlrmLGeYImi6NqcouqHnxuB1xUWTru7rrSUD2pl-skuREuD9baZlxoznuSFmY8wz5lLj3F_diD1xWT2m-h3YVKQ_oeRHPsazu4JN7zLcXoZ5nMWyKi4lH49v5pfYAnvWH_MDncHxy8g6f4Jy7KjTK5Ap3p5cy8R2Q0zVZrcSRw-tAr4Bp1viAw
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV3db9MwED-NTpp4QYzPwAZGAokXU8d27ARpQqxbtTFWTaOT9hYSxx6VRjrWVoh_bX8d53yNDsHb8mo7ce7Ovt_5zncArxU3UufC0djFlkoX5zSRMqe5FYl0PCziKpH24UjtnchPp9HpCly1d2F8WGW7J1YbdTE1_oy8j4aMRjAvJe-7JiziaGf44eIH9RWkvKe1LadRi8iB_fUTzbfZ1v4O8voN58Pd8WCPNhUGqEGgPqeFCWXBDEIYGwmHtokxLgxdXAghrGIOlbeSLo-9MzHJueYZj7MQdWYehUInWuB778CqRquI9WB1e3d0dNyd8DCBulnpOp-QEAnrG8_IyxlqXO69ecuq8C98ezNM8w-9N7wP9xrASj7WErYOK7Z8AGuHjUv-IQwG2bmZLL6TL5MzD-rLMzIpybavPEEG9Uzek2OfNopkZUHG1_e9yLiKQscRj-DkVuj2GHrltLRPgWSGFQghlGUSN22VoExJ5ZIInzApMhfAu5ZIqWnSlvvqGecpmi-equkNqgbwthtwUWfs-HfXjZbqabN0Z-m1oAXwqmvGRec9KVlppwvsU-XVSwSLA3hSM6n7FtpgqEAUC0Avsa_r4BN6L7eUk29VYm-F6Ero6Nn_p_US1lDy08_7o4PncBd_xAe8Ua42oDe_XNhNBEnz_EUjjQS-3vYC-A3BVSRl
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Calcium+Signaling+in+Brain+Cancers%3A+Roles+and+Therapeutic+Targeting&rft.jtitle=Cancers&rft.au=Maklad%2C+Ahmed&rft.au=Sharma%2C+Anjana&rft.au=Azimi%2C+Iman&rft.date=2019-01-26&rft.pub=MDPI&rft.eissn=2072-6694&rft.volume=11&rft.issue=2&rft_id=info:doi/10.3390%2Fcancers11020145&rft_id=info%3Apmid%2F30691160&rft.externalDocID=PMC6406375
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2072-6694&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2072-6694&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2072-6694&client=summon