Smad7 and Colorectal Carcinogenesis: A Double-Edged Sword

• Published in: Cancers Vol. 11; no. 5; p. 612
• Main Authors: Troncone, Edoardo, Monteleone, Giovanni
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.05.2019; MDPI
• Subjects: antisense oligonucleotides; Cancer; Carcinogenesis; Cell division; Colitis; colitis-associated cancer; colon cancer; colorectal cancer; Colorectal carcinoma; Cytokines; Disease; Gene deletion; Genes; Genome-wide association studies; Genomes; Genotype & phenotype; Growth factors; Health risk assessment; Homeostasis; Inflammatory bowel disease; Inflammatory bowel diseases; Kinases; Lymphocytes; Medical research; Mortality; Mutation; Overexpression; Phosphorylation; Proteins; Regulation; Review; Single-nucleotide polymorphism; Smad7 protein; TGF-β1 signaling; Transcription factors; colorectal cancer; TGF-β1 signaling; colon cancer; colitis-associated cancer; antisense oligonucleotides

Colorectal carcinogenesis is a complex process in which many immune and non-immune cells and a huge number of mediators are involved. Among these latter factors, Smad7, an inhibitor of the transforming growth factor (TGF)-β1 signaling that has been involved in the amplification of the inflammatory p...