A marine microbiome antifungal targets urgent-threat drug-resistant fungi

• Published in: Science (American Association for the Advancement of Science) Vol. 370; no. 6519; pp. 974 - 978
• Main Authors: Zhang, Fan, Zhao, Miao, Braun, Doug R., Ericksen, Spencer S., Piotrowski, Jeff S., Nelson, Justin, Peng, Jian, Ananiev, Gene E., Chanana, Shaurya, Barns, Kenneth, Fossen, Jen, Sanchez, Hiram, Chevrette, Marc G., Guzei, Ilia A., Zhao, Changgui, Guo, Le, Tang, Weiping, Currie, Cameron R., Rajski, Scott R., Audhya, Anjon, Andes, David R., Bugni, Tim S.
• Format: Journal Article
• Language: English
• Published: United States The American Association for the Advancement of Science 20.11.2020
• Subjects: Animals; Antifungal activity; Antifungal agents; Antifungal Agents - chemistry; Antifungal Agents - pharmacology; Antifungal Agents - therapeutic use; Benzopyrans - chemistry; Benzopyrans - pharmacology; Benzopyrans - therapeutic use; Biocompatibility; Candida - drug effects; Candida auris; Candidiasis, Invasive - drug therapy; Cutting resistance; Disease Models, Animal; Drug resistance; Drug Resistance, Multiple, Fungal; Drugs; Exploration; Fungal infections; Fungal Proteins - metabolism; Fungi; Fungicides; Infectious diseases; Isoquinolines - chemistry; Isoquinolines - pharmacology; Isoquinolines - therapeutic use; Marine animals; Marine organisms; Metabolomics; Mice; Microbiomes; Microbiota; Micromonospora - chemistry; Microorganisms; Mode of action; Multidrug resistance; Narcotics; Natural products; Pathogens; Phospholipid Transfer Proteins - metabolism; Safety; Toxicity; Urochordata - microbiology

Marine bacteria produce a plethora of natural products that often have unusual chemical structures and corresponding reactivity, which sometimes translate into a valuable biological function. Zhang et al. used a metabolomic screen to zero in on microbial strains from the microbiome of a sea squirt t...