Glucocorticoid-driven mitochondrial damage stimulates Tau pathology

• Published in: Brain (London, England : 1878) Vol. 146; no. 10; pp. 4378 - 4394
• Main Authors: Du, Fang, Yu, Qing, Swerdlow, Russell H, Waites, Clarissa L
• Format: Journal Article
• Language: English
• Published: US Oxford University Press 03.10.2023
• Subjects: Alzheimer Disease - pathology; Animals; Glucocorticoids - pharmacology; Humans; Infant; Mice; Mitochondrial Permeability Transition Pore; Original; Peptidyl-Prolyl Isomerase F; stress; tau; cyclophilin D; glucocorticoids; mPTP; mitochondria

Abstract Prolonged exposure to glucocorticoids, the main stress hormones, damages the brain and is a risk factor for depression and Alzheimer's disease. Two major drivers of glucocorticoid-related neurotoxicity are mitochondrial dysfunction and Tau pathology; however, the molecular/cellular mec...