Immunomodulatory lysophosphatidylserines are regulated by ABHD16A and ABHD12 interplay

• Published in: Nature chemical biology Vol. 11; no. 2; pp. 164 - 171
• Main Authors: Kamat, Siddhesh S, Camara, Kaddy, Parsons, William H, Chen, Dong-Hui, Dix, Melissa M, Bird, Thomas D, Howell, Amy R, Cravatt, Benjamin F
• Format: Journal Article
• Language: English
• Published: New York Nature Publishing Group US 01.02.2015; Nature Publishing Group
• Subjects: 631/250; 631/45; 631/92/287; 631/92/607; 82; 82/58; Animals; Biochemical Engineering; Biochemistry; Bioorganic Chemistry; Brain; Brain - enzymology; Brain - immunology; Brain - metabolism; Cell Biology; Cell Line; Chemistry; Chemistry/Food Science; Cytokines - immunology; Cytokines - metabolism; Hearing loss; Humans; Immunologic Factors - immunology; Immunologic Factors - metabolism; Immunology; Lipids; Lysophospholipids - immunology; Lysophospholipids - metabolism; Macrophages - enzymology; Macrophages - immunology; Macrophages - metabolism; Male; Mammals; Metabolism; Mice, Knockout; Monoacylglycerol Lipases - genetics; Mutation; Phospholipases - antagonists & inhibitors; Phospholipases - genetics; Signaling

ABHD16A is identified as a major enzyme catalyzing production of lyso-PS from phosphatidylserine (PS). A new ABHD16A inhibitor and knockout mice show a dynamic interplay occurring during inflammation between ABHD16A and disease-linked ABHD12, an enzyme that degrades lyso-PS. ABHD16A is identified as...