Late-stage myeloma invades kidney without significant effect on renal function: findings from 53 autopsies in a single institute

• Published in: International Journal of Hematology Vol. 109; no. 2; pp. 147 - 153
• Main Authors: Takano, Junichiro, Mine, Sohtaro, Mochizuki, Makoto, Tanaka, Noriko, Hagiwara, Shotaro
• Format: Journal Article
• Language: English; Japanese
• Published: Tokyo Springer Science and Business Media LLC 01.02.2019; Springer Japan; Springer Nature B.V
• Subjects: Amyloidosis; Autopsies; Autopsy; Bone marrow; Calcification; Calcinosis; Creatinine; Female; Hematology; Hepatocytes; Humans; Infections; Infiltration; Kidney Diseases; Kidneys; Light microscopy; Liver; Male; Medicine; Medicine & Public Health; Microorganisms; Middle Aged; Multiple Myeloma; Neoplasm Invasiveness; Nephropathy; Oncology; Original Article; Patients; Plasmacytosis; Renal function; Renal injury; Cast nephropathy; Renal infiltration by myeloma; Extramedullary disease; Multiple myeloma

Renal manifestations of multiple myeloma (MM) including cast nephropathy, amyloidosis, and renal calcification have been widely recognized. However, the severity of histopathological findings has not been addressed so far, and the clinical significance of these pathological findings is unclear. We s...