Strain specific effects of low level lead exposure on associative learning and memory in rats

• Published in: Neurotoxicology (Park Forest South) Vol. 62; pp. 186 - 191
• Main Authors: Verma, Megha, Schneider, J.S.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.09.2017; Elsevier BV
• Subjects: Age Factors; Animals; Animals, Newborn; Associative learning; Associative memory; Body Weight - drug effects; Brain; Cognitive ability; Conditioned stimulus; Conditioning; Conditioning, Classical - drug effects; Consolidation; Developmental lead exposure; DNA microarrays; Effects; Exposure; Fear - drug effects; Fear conditioning; Female; Females; Footshock; Gene expression; Gene Expression Regulation, Developmental - drug effects; Gestation; Hippocampus; Hippocampus - drug effects; Hippocampus - growth & development; Hippocampus - metabolism; Lead; Lead - blood; Lead - toxicity; Low level; Male; Males; Memory; Pregnancy; Prenatal Exposure Delayed Effects - chemically induced; Prenatal Exposure Delayed Effects - pathology; Prenatal Exposure Delayed Effects - physiopathology; Public health; Rats; Rats, Long-Evans; Rats, Sprague-Dawley; Recall; Retention (Psychology) - drug effects; Sex; Sex Factors; Species Specificity; Strain differences; Time Factors; Trace fear conditioning; Unconditioned stimulus; Developmental lead exposure; Strain differences; Trace fear conditioning

•The effects of Pb acetate exposure on learning and memory were differentially associated with the timing of Pb exposure (PERI or EPN), sex, and the strain (LE or SD) of the exposed animal.•Perinatally (PERI) Pb acetate exposed male LE rats showed deficits in memory consolidation and long term recal...