Reassessing the Prognostic Value of Lymph Node Metastasis in Deficient Mismatch Repair Colorectal Cancer

• Published in: Current oncology (Toronto) Vol. 32; no. 5; p. 254
• Main Authors: Ye, Zilan, Luo, Dakui, Chen, Fan, Chen, Jiayu, Shan, Zezhi, Weng, Junyong, Zhang, Yu, Li, Qingguo, Li, Xinxiang
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 27.04.2025; MDPI
• Subjects: Adult; Aged; Care and treatment; Colorectal cancer; Colorectal Neoplasms - genetics; Colorectal Neoplasms - mortality; Colorectal Neoplasms - pathology; deficient mismatch repair; DNA Mismatch Repair; Female; Humans; Immunotherapy; Ipilimumab; log odds of positive lymph nodes; lymph node metastasis; Lymphatic Metastasis - pathology; Male; Metastasis; Middle Aged; Neoplasm Staging; Patient compliance; Prognosis; prognostic factor; Retrospective Studies; deficient mismatch repair; colorectal cancer; prognostic factor; log odds of positive lymph nodes; lymph node metastasis

Background: In non-metastatic deficient mismatch repair (dMMR) colorectal cancer (CRC), traditional prognostic factors, such as pN staging, often fail to distinguish patient outcomes effectively. Methods: This retrospective study included a cohort of 792 dMMR CRC patients who underwent surgical trea...