Increased rectal microbial richness is associated with the presence of colorectal adenomas in humans

• Published in: The ISME Journal Vol. 6; no. 10; pp. 1858 - 1868
• Main Authors: Sanapareddy, Nina, Legge, Ryan M, Jovov, Biljana, McCoy, Amber, Burcal, Lauren, Araujo-Perez, Felix, Randall, Thomas A, Galanko, Joseph, Benson, Andrew, Sandler, Robert S, Rawls, John F, Abdo, Zaid, Fodor, Anthony A, Keku, Temitope O
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.10.2012; Oxford University Press; Nature Publishing Group
• Subjects: 631/326/2565/855; 692/698/2741/2135; 692/699/67/1504/1885; 692/700/139; Adenoma; Adenoma - microbiology; Adenoma - pathology; Bacteria - classification; Bacteria - genetics; Biomedical and Life Sciences; Biopsy; Case-Control Studies; Colorectal cancer; Colorectal carcinoma; Colorectal Neoplasms - microbiology; Colorectal Neoplasms - pathology; Crohn's disease; Diets; Digestive tract; DNA, Bacterial - genetics; Ecology; Evolutionary Biology; Female; Genetics; Humans; Life Sciences; Male; Metagenome; Microbial Ecology; Microbial Genetics and Genomics; Microbiology; Middle Aged; Mucosa; Obesity; Original; original-article; Rectum; Rectum - microbiology; Rectum - pathology; RNA, Ribosomal, 16S - genetics; rRNA 16S; Sequence Analysis, DNA; Titanium; Ulcerative colitis; diagnostic; commensal bacteria; colon cancer; BMI

Differences in the composition of the gut microbial community have been associated with diseases such as obesity, Crohn’s disease, ulcerative colitis and colorectal cancer (CRC). We used 454 titanium pyrosequencing of the V1–V2 region of the 16S rRNA gene to characterize adherent bacterial communiti...