Increased rectal microbial richness is associated with the presence of colorectal adenomas in humans

Differences in the composition of the gut microbial community have been associated with diseases such as obesity, Crohn’s disease, ulcerative colitis and colorectal cancer (CRC). We used 454 titanium pyrosequencing of the V1–V2 region of the 16S rRNA gene to characterize adherent bacterial communiti...

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Published in	The ISME Journal Vol. 6; no. 10; pp. 1858 - 1868
Main Authors	Sanapareddy, Nina, Legge, Ryan M, Jovov, Biljana, McCoy, Amber, Burcal, Lauren, Araujo-Perez, Felix, Randall, Thomas A, Galanko, Joseph, Benson, Andrew, Sandler, Robert S, Rawls, John F, Abdo, Zaid, Fodor, Anthony A, Keku, Temitope O
Format	Journal Article
Language	English
Published	London Nature Publishing Group UK 01.10.2012 Oxford University Press Nature Publishing Group
Subjects	631/326/2565/855 692/698/2741/2135 692/699/67/1504/1885 692/700/139 Adenoma Adenoma - microbiology Adenoma - pathology Bacteria - classification Bacteria - genetics Biomedical and Life Sciences Biopsy Case-Control Studies Colorectal cancer Colorectal carcinoma Colorectal Neoplasms - microbiology Colorectal Neoplasms - pathology Crohn's disease Diets Digestive tract DNA, Bacterial - genetics Ecology Evolutionary Biology Female Genetics Humans Life Sciences Male Metagenome Microbial Ecology Microbial Genetics and Genomics Microbiology Middle Aged Mucosa Obesity Original original-article Rectum Rectum - microbiology Rectum - pathology RNA, Ribosomal, 16S - genetics rRNA 16S Sequence Analysis, DNA Titanium Ulcerative colitis diagnostic commensal bacteria colon cancer BMI
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Abstract	Differences in the composition of the gut microbial community have been associated with diseases such as obesity, Crohn’s disease, ulcerative colitis and colorectal cancer (CRC). We used 454 titanium pyrosequencing of the V1–V2 region of the 16S rRNA gene to characterize adherent bacterial communities in mucosal biopsy samples from 33 subjects with adenomas and 38 subjects without adenomas (controls). Biopsy samples from subjects with adenomas had greater numbers of bacteria from 87 taxa than controls; only 5 taxa were more abundant in control samples. The magnitude of the differences in the distal gut microbiota between patients with adenomas and controls was more pronounced than that of any other clinical parameters including obesity, diet or family history of CRC. This suggests that sequence analysis of the microbiota could be used to identify patients at risk for developing adenomas.
AbstractList	Differences in the composition of the gut microbial community have been associated with diseases such as obesity, Crohn's disease, ulcerative colitis and colorectal cancer (CRC). We used 454 titanium pyrosequencing of the V1-V2 region of the 16S rRNA gene to characterize adherent bacterial communities in mucosal biopsy samples from 33 subjects with adenomas and 38 subjects without adenomas (controls). Biopsy samples from subjects with adenomas had greater numbers of bacteria from 87 taxa than controls; only 5 taxa were more abundant in control samples. The magnitude of the differences in the distal gut microbiota between patients with adenomas and controls was more pronounced than that of any other clinical parameters including obesity, diet or family history of CRC. This suggests that sequence analysis of the microbiota could be used to identify patients at risk for developing adenomas.Differences in the composition of the gut microbial community have been associated with diseases such as obesity, Crohn's disease, ulcerative colitis and colorectal cancer (CRC). We used 454 titanium pyrosequencing of the V1-V2 region of the 16S rRNA gene to characterize adherent bacterial communities in mucosal biopsy samples from 33 subjects with adenomas and 38 subjects without adenomas (controls). Biopsy samples from subjects with adenomas had greater numbers of bacteria from 87 taxa than controls; only 5 taxa were more abundant in control samples. The magnitude of the differences in the distal gut microbiota between patients with adenomas and controls was more pronounced than that of any other clinical parameters including obesity, diet or family history of CRC. This suggests that sequence analysis of the microbiota could be used to identify patients at risk for developing adenomas. Differences in the composition of the gut microbial community have been associated with diseases such as obesity, Crohn's disease, ulcerative colitis and colorectal cancer (CRC). We used 454 titanium pyrosequencing of the V1-V2 region of the 16S rRNA gene to characterize adherent bacterial communities in mucosal biopsy samples from 33 subjects with adenomas and 38 subjects without adenomas (controls). Biopsy samples from subjects with adenomas had greater numbers of bacteria from 87 taxa than controls; only 5 taxa were more abundant in control samples. The magnitude of the differences in the distal gut microbiota between patients with adenomas and controls was more pronounced than that of any other clinical parameters including obesity, diet or family history of CRC. This suggests that sequence analysis of the microbiota could be used to identify patients at risk for developing adenomas. Differences in the composition of the gut microbial community have been associated with diseases such as obesity, Crohn's disease, ulcerative colitis and colorectal cancer (CRC). We used 454 titanium pyrosequencing of the V1–V2 region of the 16S rRNA gene to characterize adherent bacterial communities in mucosal biopsy samples from 33 subjects with adenomas and 38 subjects without adenomas (controls). Biopsy samples from subjects with adenomas had greater numbers of bacteria from 87 taxa than controls; only 5 taxa were more abundant in control samples. The magnitude of the differences in the distal gut microbiota between patients with adenomas and controls was more pronounced than that of any other clinical parameters including obesity, diet or family history of CRC. This suggests that sequence analysis of the microbiota could be used to identify patients at risk for developing adenomas.
Author	Abdo, Zaid Jovov, Biljana Fodor, Anthony A Sandler, Robert S Sanapareddy, Nina Legge, Ryan M Rawls, John F Randall, Thomas A Keku, Temitope O Burcal, Lauren Galanko, Joseph Benson, Andrew McCoy, Amber Araujo-Perez, Felix
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PublicationSubtitle	Multidisciplinary Journal of Microbial Ecology
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PublicationYear	2012
Publisher	Nature Publishing Group UK Oxford University Press Nature Publishing Group
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Snippet	Differences in the composition of the gut microbial community have been associated with diseases such as obesity, Crohn’s disease, ulcerative colitis and... Differences in the composition of the gut microbial community have been associated with diseases such as obesity, Crohn's disease, ulcerative colitis and... Differences in the composition of the gut microbial community have been associated with diseases such as obesity, Crohn's disease, ulcerative colitis and...
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SubjectTerms	631/326/2565/855 692/698/2741/2135 692/699/67/1504/1885 692/700/139 Adenoma Adenoma - microbiology Adenoma - pathology Bacteria - classification Bacteria - genetics Biomedical and Life Sciences Biopsy Case-Control Studies Colorectal cancer Colorectal carcinoma Colorectal Neoplasms - microbiology Colorectal Neoplasms - pathology Crohn's disease Diets Digestive tract DNA, Bacterial - genetics Ecology Evolutionary Biology Female Genetics Humans Life Sciences Male Metagenome Microbial Ecology Microbial Genetics and Genomics Microbiology Middle Aged Mucosa Obesity Original original-article Rectum Rectum - microbiology Rectum - pathology RNA, Ribosomal, 16S - genetics rRNA 16S Sequence Analysis, DNA Titanium Ulcerative colitis
Title	Increased rectal microbial richness is associated with the presence of colorectal adenomas in humans
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