Combined liver–cytokine humanization comes to the rescue of circulating human red blood cells - Song, Yuanbin; Shan, Liang; Gbyli, Rana; Liu, Wei; Strowig, Till; Patel, Amisha; Fu, Xiaoying; Wang, Xiaman; Xu, Mina L.; Gao, Yimeng; Qin, Ashley; Bruscia, Emanuela M.; et al. (Science (American Association for the Advancement of Science), 2021)
Keywords: Anemia, Sickle Cell - blood; Animal models; Animals; Blood; Blood Circulation; Bone marrow; Cell density; Complement component C3; CRISPR; Cytokines; Cytokines - metabolism; Disease Models, Animal; Erythrocytes; Erythrocytes - cytology; Erythropoiesis; Erythropoiesis - genetics; Erythropoiesis - physiology; Female; Fetuses; Fumarylacetoacetase; Gene Deletion; Genetic engineering; Hematopoiesis; Hematopoietic Stem Cells - cytology; Hepatocytes; Humanization; Humans; Hydrolases - genetics; Immunodeficiency; In vivo methods and tests; Infectious diseases; Liver; Liver - physiology; Liver transplantation; Malaria; Mice; Mice, Mutant Strains; Middle Aged; Occlusion; Pathology; Sickle cell disease; Stem cell transplantation; Stem cells; Survival; Vector-borne diseases