Neutrophil extracellular traps (NETs) are increased in rheumatoid arthritis-associated interstitial lung disease

• Published in: Respiratory research Vol. 26; no. 1; pp. 33 - 19
• Main Authors: Xue, Jing, Nian, Miaomiao, Liang, Yangyang, Zhu, Zeqin, Hu, Zhenyu, Jia, Yuanyuan, Chi, Shuhong, Chen, Juan
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 22.01.2025; BioMed Central; BMC
• Subjects: Aged; Animals; Arthritis, Rheumatoid - complications; Arthritis, Rheumatoid - metabolism; Complications and side effects; Extracellular Traps - metabolism; Female; Health aspects; HL-60 Cells; Humans; Interstitial lung disease; Lung diseases, Interstitial; Lung Diseases, Interstitial - metabolism; Lung Diseases, Interstitial - pathology; Male; Medical research; Medicine, Experimental; Mice; Middle Aged; Neutrophil extracellular traps; Neutrophils; Neutrophils - metabolism; Neutrophils - pathology; Nuclear receptor 4; Physiological aspects; Rheumatoid arthritis; Risk factors; China; Nuclear receptor 4; Interstitial lung disease; Neutrophil extracellular traps; Rheumatoid arthritis
• ISSN: 1465-993X; 1465-9921; 1465-993X
• DOI: 10.1186/s12931-025-03111-1

Neutrophil extracellular trap (NET) formation has been implicated as a pathogenic mechanism in both rheumatoid arthritis (RA) and interstitial lung disease (ILD). However, the role of NETs in RA-associated ILD (RA-ILD) and the mechanisms driving NET formation remain unclear. This study aimed to asse...