Are Delta-Aminolevulinate Dehydratase Inhibition and Metal Concentrations Additional Factors for the Age-Related Cognitive Decline?

• Published in: International journal of environmental research and public health Vol. 11; no. 10; pp. 10851 - 10867
• Main Authors: Baierle, Marília, Charão, Mariele, Göethel, Gabriela, Barth, Anelise, Fracasso, Rafael, Bubols, Guilherme, Sauer, Elisa, Campanharo, Sarah, Rocha, Rafael, Saint'Pierre, Tatiana, Bordignon, Suelen, Zibetti, Murilo, Trentini, Clarissa, Ávila, Daiana, Gioda, Adriana, Garcia, Solange
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 17.10.2014; MDPI
• Subjects: Adult; Aged; Brazil - epidemiology; Cognition; Cognition Disorders - blood; Cognition Disorders - enzymology; Cognition Disorders - epidemiology; Cognitive ability; Enzyme Inhibitors - blood; Enzyme Inhibitors - toxicity; Female; Hazardous materials; Humans; Male; Medical disorders; Metals, Heavy - blood; Metals, Heavy - toxicity; Middle Aged; Oxidative Stress; Porphobilinogen Synthase - antagonists & inhibitors; Porphobilinogen Synthase - blood; Risk factors; Selenium - deficiency; Brazil

Aging is often accompanied by cognitive impairments and influenced by oxidative status and chemical imbalances. Thus, this study was conducted to examine whether age-related cognitive deficit is associated with oxidative damage, especially with inhibition of the enzyme delta-aminolevulinate dehydrat...