Central nervous and cardiovascular effects of i.v. infusions of ropivacaine, bupivacaine and placebo in volunteers

• Published in: British journal of anaesthesia : BJA Vol. 78; no. 5; pp. 507 - 514
• Main Authors: Knudsen, K, Beckman Suurküla, M, Blomberg, S, Sjövall, J, Edvardsson, N
• Format: Journal Article
• Language: English
• Published: Oxford Elsevier Ltd 01.05.1997; Oxford University Press; Oxford Publishing Limited (England)
• Subjects: Adult; Amides - adverse effects; Amides - blood; Amides - pharmacology; Anesthetics, Local - adverse effects; Anesthetics, Local - blood; Anesthetics, Local - pharmacology; Biological and medical sciences; Bupivacaine - adverse effects; Bupivacaine - blood; Bupivacaine - pharmacology; Central Nervous System Diseases - chemically induced; Cross-Over Studies; Double-Blind Method; Drug Administration Schedule; Drug toxicity and drugs side effects treatment; Electrocardiography - drug effects; Hemodynamics - drug effects; Humans; Infusions, Intravenous; Male; Medical sciences; Pharmacology. Drug treatments; Ropivacaine; Toxicity: nervous system and muscle; Ventricular Function, Left - drug effects; Human; Nervous system diseases; Echocardiography; Intravenous administration; Toxicity; Cardiovascular disease; Ropivacaine; Local anesthetic; Bupivacaine; Activity concentration relation; Central nervous system disease; Electrocardiography; Hemodynamics; Anilide; Comparative study

We have compared the incidence of CNS symptoms and changes in echocardiography and electrophysiology during i.v. infusions of ropivacaine, bupivacaine and placebo. Acute tolerance of i.v. infusion of 10 mg min-1 was studied in a crossover, randomized, double-blind study in 12 volunteers previously a...