MicroRNA in Lung Cancer Metastasis

• Published in: Cancers Vol. 11; no. 2; p. 265
• Main Authors: Wu, Shang-Gin, Chang, Tzu-Hua, Liu, Yi-Nan, Shih, Jin-Yuan
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 23.02.2019; MDPI
• Subjects: Angiogenesis; Apoptosis; Cell growth; Clinical trials; Drug resistance; Epidermal growth factor; Extracellular matrix; Gene expression; Genotype & phenotype; Invasiveness; Kinases; Lung cancer; Mesenchyme; Metastases; Metastasis; MicroRNAs; miRNA; Non-coding RNA; Post-transcription; Proteins; Review; Transcription factors; lung cancer; microRNA; metastasis; epithelial-to-mesenchymal transition

Tumor metastasis is a hallmark of cancer, with distant metastasis frequently developing in lung cancer, even at initial diagnosis, resulting in poor prognosis and high mortality. However, available biomarkers cannot reliably predict cancer spreading sites. The metastatic cascade involves highly comp...