Interhemispheric inhibition of corticospinal projections to forearm muscles
Highlights • Elicitation of interhemispheric inhibition is demonstrated for projections to muscles that flex and extend the wrist. • The degree of inhibition is a monotonic function of conditioning stimulus intensity. • Inhibition was most pronounced at an inter-stimulus interval of 10 ms.
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| Published in | Clinical neurophysiology Vol. 126; no. 10; pp. 1934 - 1940 |
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| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
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Netherlands
Elsevier Ireland Ltd
01.10.2015
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| Abstract | Highlights • Elicitation of interhemispheric inhibition is demonstrated for projections to muscles that flex and extend the wrist. • The degree of inhibition is a monotonic function of conditioning stimulus intensity. • Inhibition was most pronounced at an inter-stimulus interval of 10 ms. |
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| AbstractList | Interhemispheric inhibition (IHI) is typically examined via responses elicited in intrinsic hand muscles. As the cortical representations of proximal and distal muscles in the upper limb are distinguished in terms of their inter-hemispheric projections, we sought to determine whether the IHI parameters established for the hand apply more generally.
We investigated IHI at 5 different conditioning stimulus (CS) intensities and a range of short-latency inter-stimulus intervals (ISIs) in healthy participants. Conditioning and test stimuli were delivered over the M1 representation of the right and left flexor carpi radialis respectively.
IHI increased as a function of CS intensity, and was present for ISIs between 7 and 15ms. Inhibition was most pronounced for the 10ms ISI at all CS intensities.
The range of parameters for which IHI is elicited in projections to the forearm is similar to that reported for the hand. The specific utility lies in delineation of stimulus parameters that permit both potentiation and attenuation of IHI to be assessed.
In light of evidence that there is a greater density of callosal projections between cortical areas that represent proximal muscles than between those corresponding to distal limb muscles, and in view of the assumption that variations in functional connectivity to which such differences give rise may have important implications for motor behavior, it is critical to determine whether processes mediating the expression of IHI depend on the effector that is studied. This issue is of further broad significance given the practical utility of movements generated by muscles proximal to the wrist in the context of upper limb rehabilitation. •Elicitation of interhemispheric inhibition is demonstrated for projections to muscles that flex and extend the wrist.•The degree of inhibition is a monotonic function of conditioning stimulus intensity.•Inhibition was most pronounced at an inter-stimulus interval of 10ms. Interhemispheric inhibition (IHI) is typically examined via responses elicited in intrinsic hand muscles. As the cortical representations of proximal and distal muscles in the upper limb are distinguished in terms of their inter-hemispheric projections, we sought to determine whether the IHI parameters established for the hand apply more generally. We investigated IHI at 5 different conditioning stimulus (CS) intensities and a range of short-latency inter-stimulus intervals (ISIs) in healthy participants. Conditioning and test stimuli were delivered over the M1 representation of the right and left flexor carpi radialis respectively. IHI increased as a function of CS intensity, and was present for ISIs between 7 and 15ms. Inhibition was most pronounced for the 10ms ISI at all CS intensities. The range of parameters for which IHI is elicited in projections to the forearm is similar to that reported for the hand. The specific utility lies in delineation of stimulus parameters that permit both potentiation and attenuation of IHI to be assessed. In light of evidence that there is a greater density of callosal projections between cortical areas that represent proximal muscles than between those corresponding to distal limb muscles, and in view of the assumption that variations in functional connectivity to which such differences give rise may have important implications for motor behavior, it is critical to determine whether processes mediating the expression of IHI depend on the effector that is studied. This issue is of further broad significance given the practical utility of movements generated by muscles proximal to the wrist in the context of upper limb rehabilitation. Highlights • Elicitation of interhemispheric inhibition is demonstrated for projections to muscles that flex and extend the wrist. • The degree of inhibition is a monotonic function of conditioning stimulus intensity. • Inhibition was most pronounced at an inter-stimulus interval of 10 ms. OBJECTIVEInterhemispheric inhibition (IHI) is typically examined via responses elicited in intrinsic hand muscles. As the cortical representations of proximal and distal muscles in the upper limb are distinguished in terms of their inter-hemispheric projections, we sought to determine whether the IHI parameters established for the hand apply more generally.METHODSWe investigated IHI at 5 different conditioning stimulus (CS) intensities and a range of short-latency inter-stimulus intervals (ISIs) in healthy participants. Conditioning and test stimuli were delivered over the M1 representation of the right and left flexor carpi radialis respectively.RESULTSIHI increased as a function of CS intensity, and was present for ISIs between 7 and 15ms. Inhibition was most pronounced for the 10ms ISI at all CS intensities.CONCLUSIONSThe range of parameters for which IHI is elicited in projections to the forearm is similar to that reported for the hand. The specific utility lies in delineation of stimulus parameters that permit both potentiation and attenuation of IHI to be assessed.SIGNIFICANCEIn light of evidence that there is a greater density of callosal projections between cortical areas that represent proximal muscles than between those corresponding to distal limb muscles, and in view of the assumption that variations in functional connectivity to which such differences give rise may have important implications for motor behavior, it is critical to determine whether processes mediating the expression of IHI depend on the effector that is studied. This issue is of further broad significance given the practical utility of movements generated by muscles proximal to the wrist in the context of upper limb rehabilitation. |
| Author | Bolton, D.A.E Staines, W.R Carson, R.G Ibey, R.J Buick, A.R |
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| CitedBy_id | crossref_primary_10_1016_j_jpain_2023_08_013 crossref_primary_10_1016_j_neubiorev_2021_11_025 crossref_primary_10_1016_j_nicl_2016_07_008 crossref_primary_10_1016_j_clinph_2020_07_020 crossref_primary_10_1136_jnnp_2018_319581 |
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| Keywords | Interhemispheric inhibition Electromyography Upper limb Proximal muscles Transcranial magnetic stimulation |
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| Snippet | Highlights • Elicitation of interhemispheric inhibition is demonstrated for projections to muscles that flex and extend the wrist. • The degree of inhibition... •Elicitation of interhemispheric inhibition is demonstrated for projections to muscles that flex and extend the wrist.•The degree of inhibition is a monotonic... Interhemispheric inhibition (IHI) is typically examined via responses elicited in intrinsic hand muscles. As the cortical representations of proximal and... OBJECTIVEInterhemispheric inhibition (IHI) is typically examined via responses elicited in intrinsic hand muscles. As the cortical representations of proximal... |
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| SubjectTerms | Adult Electromyography Electromyography - methods Evoked Potentials, Motor - physiology Female Forearm - innervation Forearm - physiology Humans Interhemispheric inhibition Motor Cortex - physiology Neural Inhibition - physiology Neurology Proximal muscles Pyramidal Tracts - physiology Transcranial magnetic stimulation Transcranial Magnetic Stimulation - methods Upper limb Young Adult |
| Title | Interhemispheric inhibition of corticospinal projections to forearm muscles |
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