Homologous recombination and the yKu70/80 complex exert opposite roles in resistance against the killer toxin from Pichia acaciae

• Published in: DNA repair Vol. 6; no. 12; pp. 1864 - 1875
• Main Authors: Klassen, Roland, Krampe, Stefan, Meinhardt, Friedhelm
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 01.12.2007; Elsevier
• Subjects: Antigens, Nuclear - genetics; Bacteriology; Base Sequence; Biological and medical sciences; DNA Damage; DNA Primers; DNA-Binding Proteins - genetics; Electrophoresis, Gel, Pulsed-Field; Fundamental and applied biological sciences. Psychology; Growth, nutrition, cell differenciation; Histone H2A; Histones - metabolism; Homologous recombination; Killer; Killer Factors, Yeast; Ku Autoantigen; Microbiology; Molecular and cellular biology; Molecular genetics; Mutagenesis. Repair; Mycotoxins - pharmacology; Non-homologous end joining; Phosphorylation; Pichia; Pichia - metabolism; Recombination, Genetic; Saccharomyces cerevisiae; Histone H2A; Homologous recombination; Killer; Non-homologous end joining; Ascomycota; Fungi; Resistance; Toxin; DNA; Repair; Complexes; Killer,Homologous recombination,Non-homologous end joining,Histone H2A; Pichia

The linear plasmid (pPac1-2) encoded killer toxin (PaT) of the yeast Pichia acaciae arrests sensitive Saccharomyces cerevisiae cells in the S-phase of the cell cycle and induces mutations. Here we provide evidence for opposite effects in PaT resistance of homologous recombination (HR) and non-homolo...